Neuronal regulation of alternative pre-mRNA splicing

被引：289

作者：

Li, Qin

Lee, Ji-Ann

Black, Douglas L.

机构：

[1] Univ Calif Los Angeles, Howard Hughes Med Inst, Los Angeles, CA 90095 USA

[2] Univ Calif Los Angeles, Dept Microbiol Mol Genet & Immunol, Los Angeles, CA 90095 USA

来源：

NATURE REVIEWS NEUROSCIENCE | 2007年 / 8卷 / 11期

关键词：

D O I：

10.1038/nrn2237

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Alternative pre-mRNA splicing has an important role in the control of neuronal gene expression. Many neuronal proteins are structurally diversified through the differential inclusion and exclusion of sequences in the final spliced mRNA. Here, we discuss common mechanisms of splicing regulation and provide examples of how alternative splicing has important roles in neuronal development and mature neuron function. Finally, we describe regulatory proteins that control the splicing of some neuronally expressed transcripts.

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页码：819 / 831

页数：13

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