Modelling Cardiac Tissue Growth and Remodelling

Cardiac growth and remodelling are key phenomena influencing the physiological performance of the heart and progression of various cardiac diseases. Our basic knowledge of the characteristics of cardiac growth and remodelling have benefitted from the study of the corresponding changes in tissue structure. Computational modelling is capable of integrating multi-scale biological and physiological information of the heart to better delineate the mechanisms underpinning normal physiological and abnormal pathological cardiac processes. In this article, we summarise recent state-of-the-art modelling studies of cardiac growth and remodelling in health and disease, demonstrate the use of finite element modelling approach in simulating growth of an embryonic linear heart tube and towards understanding the roles of structural remodelling in heart failure.