The therapeutic effect of probiotics on rheumatoid arthritis: a systematic review and meta-analysis of randomized control trials

被引：78

作者：

Mohammed, Abdelrahman Tarek ^{[1
]}

Khattab, Mohammed ^{[1
]}

Ahmed, Ali Mahmoud ^{[1
]}

Turk, Tarek ^{[2
]}

Sakr, Nora ^{[3
]}

Khalil, Adham M. ^{[4
]}

Abdelhalim, Mohamed ^{[4
]}

Sawaf, Bisher ^{[5
]}

Hirayama, Kenji ^{[6
,7
]}

Nguyen Tien Huy ^{[7
,8
,9
,10
]}

机构：

[1] Al Azhar Univ, Fac Med, Cairo 11884, Egypt

[2] Damascus Univ, Fac Med, Damascus, Syria

[3] Menoufia Univ, Fac Med, Menoufia, Egypt

[4] Zagazig Univ, Fac Med, Zagazig 44519, Egypt

[5] Syrian Private Univ, Fac Med, Damascus, Syria

[6] Nagasaki Univ, Dept Immunogenet, Inst Trop Med NEKKEN, Leading Grad Sch Program, 1-12-4 Sakamoto, Nagasaki 8528523, Japan

[7] Nagasaki Univ, Grad Sch Biomed Sci, 1-12-4 Sakamoto, Nagasaki 8528523, Japan

[8] Ton Duc Thang Univ, Evidence Based Med Res Grp, Ho Chi Minh City, Vietnam

[9] Nagasaki Univ, Leading Grad Sch Program, Dept Clin Prod Dev, Inst Trop Med NEKKEN, 1-12-4 Sakamoto, Nagasaki 8528523, Japan

[10] Univ Med & Pharm Ho Chi Minh City, Ctr Mol Biomed, 217 Hong Bang,Dist 5, Ho Chi Minh 70000, Vietnam

来源：

CLINICAL RHEUMATOLOGY | 2017年 / 36卷 / 12期

关键词：

Cytokines; Disease activity score; Meta-analysis; Probiotics; Rheumatoid arthritis; Systematic review; LACTOBACILLUS-CASEI; DOUBLE-BLIND; DISEASE-ACTIVITY; SUPPLEMENTATION; PATHOGENESIS; CYTOKINES; BACTERIA; FLORA; FOOD;

D O I：

10.1007/s10067-017-3814-3

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Rheumatoid arthritis is an autoimmune disease in which probiotics appears to have an immune modulating action along with decreased inflammatory process. Therefore, we aim to investigate the efficacy of probiotics as an adjuvant therapy for rheumatoid arthritis. A comprehensive literature search was performed using nine databases including PubMed and Web of Science. Interesting data was extracted and meta-analyzed. We assessed the risk of bias using Cochrane Collaboration's tool. The protocol was registered in PROSPERO (CRD 42016036769). We found nine studies involving 361 patients who met our eligibility criteria. Our meta-analysis indicated that pro-inflammatory cytokine IL-6 was significantly lower in the probiotics compared with the placebo group (standardized mean difference = - 0.708; 95% confidence interval (CI) - 1.370 to 0.047, P = 0.036). However, there was no difference between probiotics and placebo in disease activity score (mean difference 0.023; 95% CI - 0.584 to 0.631, P = 0.940). Probiotics lowered pro-inflammatory cytokines IL-6 in RA; however, its clinical effect is still unclear. Hence, many high-quality randomized controlled trials (RCTs) are still needed to prove this effect.

引用

页码：2697 / 2707

页数：11

共 37 条

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