An Efficient and General Synthesis of Primary Amines by Ruthenium-Catalyzed Amination of Secondary Alcohols with Ammonia

被引：269

作者：

Imm, Sebastian ^{[1
]}

Baehn, Sebastian ^{[1
]}

Neubert, Lorenz ^{[1
]}

Neumann, Helfried ^{[1
]}

Beller, Matthias ^{[1
]}

机构：

[1] Univ Rostock eV, Leibniz Inst Katalyse, D-18059 Rostock, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2010年 / 49卷 / 44期

关键词：

alcohols; amines; ammonia; homogeneous catalysis; ruthenium; N BOND FORMATION; BORROWING HYDROGEN; ALKYLATION; HYDROAMINATION; DIAMINES; INDOLES;

D O I：

10.1002/anie.201002576

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Atom efficiency and selectivity are the key features of the first homogeneously catalyzed amination of secondary alcohols with ammonia to give the corresponding primary amines (see scheme). This novel amination method relies on the commercially available catalyst [Ru3(CO)12]/ cataCXium PCy and does not require any additional source of hydrogen. © 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：8126 / 8129

页数：4

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