Intradialytic Changes of Plasma Amino Acid Levels: Effect of Hemodiafiltration with Endogenous Reinfusion versus Acetate-Free Biofiltration

被引：7

作者：

Borrelli, S. ^{[1
]}

Minutolo, R. ^{[1
]}

De Nicola, L. ^{[1
]}

Zamboli, P. ^{[1
]}

Iodice, C. ^{[1
]}

De Paola, A. ^{[1
]}

De Simone, E. ^{[2
]}

Zito, B. ^{[2
]}

Guastaferro, P. ^{[3
]}

Nigro, F. ^{[3
]}

Apperti, V. ^{[4
]}

Iulianiello, G. ^{[4
]}

Credendino, O. ^{[5
]}

Iacono, G. ^{[6
]}

Di Serafino, A. ^{[7
]}

D'Apice, L. ^{[8
]}

Saviano, C. ^{[8
]}

Sarti, A. ^{[9
]}

Capuano, M. ^{[10
]}

Genualdo, R. ^{[10
]}

Auricchio, M. ^{[11
]}

Merola, M. ^{[11
]}

Conte, G. ^{[1
]}

机构：

[1] Univ Naples 2, SMdP Incurabili Hosp ASL NA1, IT-80138 Naples, Italy

[2] G Moscati Hosp Avellino, Avellino, Italy

[3] G Criscuoli Hosp S Angelo Lombardi, S Angelo Dei Lombardi, Italy

[4] Melorio Hosp S Felice Cancello, San Felice A Cancello, Italy

[5] A Cardarelli Hosp Naples, Naples, Italy

[6] A Rizzoli Hosp Ischia, Ischia, Italy

[7] S Giovanni di Dio & Ruggi dAragona Hosp Salerno, Salerno, Italy

[8] Civil Hosp Caserta, Caserta, Italy

[9] M Scarlato Hosp Scafati, Scafati, Italy

[10] Trinita Pellegrini Hosp Naples, Naples, Italy

[11] Osped Riuniti Area Stabiese Castellammare Stabia, Castellammare Di Stabia, Italy

来源：

BLOOD PURIFICATION | 2010年 / 30卷 / 03期

关键词：

Hemodiafiltration with endogenous reinfusion; Acetate-free biofiltration; Amino acid profile; NUTRITION IMPROVES PROTEIN; CHRONIC-HEMODIALYSIS; HOMEOSTASIS; MECHANISMS; ANOREXIA; LOSSES;

D O I：

10.1159/000320133

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

During hemodialysis, amino acids (AA) are lost in the ultrafiltrate with consequent modification of their plasma profile. The aim of this cross-sectional study was to evaluate intradialytic changes of plasma AA levels during a single session of hemodiafiltration with endogenous reinfusion (HFR) versus acetate-free biofiltration (AFB). 48 patients chronically treated with HFR or AFB were matched 1: 1 for age, gender, Kt/V and diabetes. Blood samples were collected at the beginning and the end of dialysis. Baseline plasma levels (mu mol/l) of total AA (3,176 +/- 722), essential AA (889 +/- 221), and branched chain AA (459 +/- 140) levels in HFR were similar to those in AFB (3,399 +/- 621, 938 +/- 277, and 463 +/- 71, respectively). Plasma intradialytic AA levels did not change in HFR, while in AFB there was a reduction by about 25%. In conclusion, as compared with AFB, HFR has a sparing effect on AA loss due to the lack of adsorption by cartridge and to their complete reinfusion in blood. Copyright (C) 2010 S. Karger AG, Basel

引用

页码：166 / 171

页数：6

共 26 条

[21] Pupim LB, 2002, J CLIN INVEST, V110, P483, DOI [10.1172/JCI200215449, 10.1172/JCI0215449]
[22] Factors predicting malnutrition in hemodialysis patients:: A cross-sectional study
Qureshi, AR
Alvestrand, A
Danielsson, A
Divino, JC
Gutierrez, A
Lindholm, B
Bergström, J
[J]. KIDNEY INTERNATIONAL, 1998, 53 (03) : 773 - 782
[23] Ragazzoni E, 2004, G Ital Nefrol, V21 Suppl 30, pS85
[24] MECHANISMS CAUSING MUSCLE LOSS IN CHRONIC-RENAL-FAILURE
REAICH, D
PRICE, SR
ENGLAND, BK
MITCH, WE
[J]. AMERICAN JOURNAL OF KIDNEY DISEASES, 1995, 26 (01) : 242 - 247
[25] AMINO-ACID LOSSES DURING HEMODIALYSIS WITH INFUSION OF AMINO-ACIDS AND GLUCOSE
WOLFSON, M
JONES, MR
KOPPLE, JD
[J]. KIDNEY INTERNATIONAL, 1982, 21 (03) : 500 - 506
[26] ANTHROPOMETRY AND PLASMA VALINE, AMINO-ACIDS, AND PROTEINS IN THE NUTRITIONAL ASSESSMENT OF HEMODIALYSIS-PATIENTS
YOUNG, GA
SWANEPOEL, CR
CROFT, MR
HOBSON, SM
PARSONS, FM
[J]. KIDNEY INTERNATIONAL, 1982, 21 (03) : 492 - 499

← 1 2 3 →