Intradialytic Changes of Plasma Amino Acid Levels: Effect of Hemodiafiltration with Endogenous Reinfusion versus Acetate-Free Biofiltration

被引：7

作者：

Borrelli, S. ^{[1
]}

Minutolo, R. ^{[1
]}

De Nicola, L. ^{[1
]}

Zamboli, P. ^{[1
]}

Iodice, C. ^{[1
]}

De Paola, A. ^{[1
]}

De Simone, E. ^{[2
]}

Zito, B. ^{[2
]}

Guastaferro, P. ^{[3
]}

Nigro, F. ^{[3
]}

Apperti, V. ^{[4
]}

Iulianiello, G. ^{[4
]}

Credendino, O. ^{[5
]}

Iacono, G. ^{[6
]}

Di Serafino, A. ^{[7
]}

D'Apice, L. ^{[8
]}

Saviano, C. ^{[8
]}

Sarti, A. ^{[9
]}

Capuano, M. ^{[10
]}

Genualdo, R. ^{[10
]}

Auricchio, M. ^{[11
]}

Merola, M. ^{[11
]}

Conte, G. ^{[1
]}

机构：

[1] Univ Naples 2, SMdP Incurabili Hosp ASL NA1, IT-80138 Naples, Italy

[2] G Moscati Hosp Avellino, Avellino, Italy

[3] G Criscuoli Hosp S Angelo Lombardi, S Angelo Dei Lombardi, Italy

[4] Melorio Hosp S Felice Cancello, San Felice A Cancello, Italy

[5] A Cardarelli Hosp Naples, Naples, Italy

[6] A Rizzoli Hosp Ischia, Ischia, Italy

[7] S Giovanni di Dio & Ruggi dAragona Hosp Salerno, Salerno, Italy

[8] Civil Hosp Caserta, Caserta, Italy

[9] M Scarlato Hosp Scafati, Scafati, Italy

[10] Trinita Pellegrini Hosp Naples, Naples, Italy

[11] Osped Riuniti Area Stabiese Castellammare Stabia, Castellammare Di Stabia, Italy

来源：

BLOOD PURIFICATION | 2010年 / 30卷 / 03期

关键词：

Hemodiafiltration with endogenous reinfusion; Acetate-free biofiltration; Amino acid profile; NUTRITION IMPROVES PROTEIN; CHRONIC-HEMODIALYSIS; HOMEOSTASIS; MECHANISMS; ANOREXIA; LOSSES;

D O I：

10.1159/000320133

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

During hemodialysis, amino acids (AA) are lost in the ultrafiltrate with consequent modification of their plasma profile. The aim of this cross-sectional study was to evaluate intradialytic changes of plasma AA levels during a single session of hemodiafiltration with endogenous reinfusion (HFR) versus acetate-free biofiltration (AFB). 48 patients chronically treated with HFR or AFB were matched 1: 1 for age, gender, Kt/V and diabetes. Blood samples were collected at the beginning and the end of dialysis. Baseline plasma levels (mu mol/l) of total AA (3,176 +/- 722), essential AA (889 +/- 221), and branched chain AA (459 +/- 140) levels in HFR were similar to those in AFB (3,399 +/- 621, 938 +/- 277, and 463 +/- 71, respectively). Plasma intradialytic AA levels did not change in HFR, while in AFB there was a reduction by about 25%. In conclusion, as compared with AFB, HFR has a sparing effect on AA loss due to the lack of adsorption by cartridge and to their complete reinfusion in blood. Copyright (C) 2010 S. Karger AG, Basel

引用

页码：166 / 171

页数：6

共 26 条

[1] Eating behavior disorders in uremia:: A question of balance in appetite regulation
Aguilera, A
Codoceo, R
Bajo, MA
Iglesias, P
Diéz, JJ
Barril, G
Cigarrán, S
Alvarez, V
Celadilla, O
Fernández-Perpén, A
Montero, A
Selgas, R
[J]. SEMINARS IN DIALYSIS, 2004, 17 (01) : 44 - 52
[2] WHY ARE DIALYSIS PATIENTS MALNOURISHED
BERGSTROM, J
[J]. AMERICAN JOURNAL OF KIDNEY DISEASES, 1995, 26 (01) : 229 - 241
[3] Anorexia in hemodialysis patients: An update
Bossola, M.
Tazza, L.
Giungi, S.
Luciani, G.
[J]. KIDNEY INTERNATIONAL, 2006, 70 (03) : 417 - 422
[4] Mechanisms and Treatment of Anorexia in End-Stage Renal Disease Patients on Hemodialysis
Bossola, Maurizio
Tazza, Luigi
Luciani, Giovanna
[J]. JOURNAL OF RENAL NUTRITION, 2009, 19 (01) : 2 - 9
[5] Mortality risk for patients receiving hemodiafiltration versus hemodialysis: European results from the DOPPS
Canaud, B.
Bragg-Gresham, J. L.
Marshall, M. R.
Desmeules, S.
Gillespie, B. W.
Depner, T.
Klassen, P.
Port, F. K.
[J]. KIDNEY INTERNATIONAL, 2006, 69 (11) : 2087 - 2093
[6] EFFECT OF INTRADIALYTIC PARENTERAL-NUTRITION ON MORTALITY-RATES IN END-STAGE RENAL-DISEASE CARE
CAPELLI, JP
KUSHNER, H
CAMISCIOLI, TC
CHEN, SM
TORRES, MA
[J]. AMERICAN JOURNAL OF KIDNEY DISEASES, 1994, 23 (06) : 808 - 816
[7] Malnutrition in long-term haemodialysis survivors
Chazot, C
Laurent, G
Charra, B
Blanc, C
VoVan, C
Jean, G
Vanel, T
Terrat, JC
Ruffet, M
[J]. NEPHROLOGY DIALYSIS TRANSPLANTATION, 2001, 16 (01) : 61 - 69
[8] THE ASSOCIATION OF INTRADIALYTIC PARENTERAL-NUTRITION ADMINISTRATION WITH SURVIVAL IN HEMODIALYSIS-PATIENTS
CHERTOW, GM
LING, J
LEW, NL
LAZARUS, JM
LOWRIE, EG
[J]. AMERICAN JOURNAL OF KIDNEY DISEASES, 1994, 24 (06) : 912 - 920
[9] Hemodiafiltration with online regeneration of the ultrafiltrate
de Francisco, ALM
Ghezzi, PM
Brendolan, A
Fiorini, F
La Greca, G
Ronco, C
Arias, M
Gervasio, R
Tetta, C
[J]. KIDNEY INTERNATIONAL, 2000, 58 : S66 - S71
[10] Haemodiafiltration with sorbent-regenerated ultrafiltrate as replacement fluid: A multicenter study
deFrancisco, ALM
Botella, J
Escallada, R
Hernandez, J
Malo, AM
Garcia, RP
Tomero, JAS
Sanz, C
[J]. NEPHROLOGY DIALYSIS TRANSPLANTATION, 1997, 12 (03) : 528 - 534

← 1 2 3 →