Plants used in Guatemala for the treatment of protozoal infections -: II.: Activity of extracts and fractions of five Guatemalan plants against Trypanosoma cruzi

被引:42
作者
Berger, I [1 ]
Barrientos, AC
Cáceres, A
Hernández, M
Rastrelli, L
Passreiter, CM
Kubelka, W
机构
[1] Univ Vienna, Inst Pharmacognosy, Vienna, Austria
[2] Univ San Carlos, Fac Chem Sci & Pharm, Sch Biol Chem, Guatemala City, Guatemala
[3] Univ San Carlos, Fac Chem Sci & Pharm, Inst Chem & Biol Invest, Guatemala City, Guatemala
[4] Univ Salerno, Fac Pharm, Dept Phytochem, I-84100 Salerno, Italy
[5] Univ Dusseldorf, Dept Pharmaceut Biol, D-4000 Dusseldorf, Germany
关键词
Trypanosoma cruzi; medicinal plants; antiprotozoal activity; Guatemala;
D O I
10.1016/S0378-8741(98)00011-7
中图分类号
Q94 [植物学];
学科分类号
071001 ;
摘要
The activities of crude plant extracts of five plants popularly used in Guatemala against bacterial and protozoal infections and some of their fractions have been evaluated against the trypomastigote and epimastigote forms of Trypanosoma cruzi in vitro. The most active fraction of Neurolaena lobata has also been screened in vivo. Main in vitro activities against trypomastigotes have been observed for the hexane and ethanol extracts of N. lobata (Asteraceae). Both extracts were also active against epimastigotes, whereas all other extracts tested had no effect on epimastigotes. For the hexane extracts of Petiveria alliacea (Phytolaccaceae) and Tridax procumbens (Asteraceae) a marked inhibition of trypomastigotes has been found. Also the ethanol extracts of Byrsonima crassifolia (Malpighiaceae) leafs and Gliricidia sepium (Papilionaceae) bark showed some trypanocidal activity. Fraction 2 of the ethanol extract of N. lobata was highly active against T. cruzi as well in vitro as in vivo. The chloroforme fraction of P. alliacea showed a high inhibition of trypomastigotes in vitro. Also three ii-actions of the active extract of B. crassifolia inhibited T. cruzi trypomastigotes. No fraction of G. sepium bark extract showed a marked trypanocidal activity. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.
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页码:107 / 115
页数:9
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