The role of Toll-like receptors in the host response to viruses

被引：192
|
作者：
Bowie, AG [1 ]
Haga, IR [1 ]
机构：
[1] Trinity Coll Dublin, Dept Biochem, Dublin 2, Ireland
来源：
MOLECULAR IMMUNOLOGY | 2005年 / 42卷 / 08期
基金：
爱尔兰科学基金会;
关键词：
innate immunity; Toll-like receptors; NF kappa B; IRF3; IFN; virus;
D O I：
10.1016/j.molimm.2004.11.007
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The discovery of Toll-like receptors (TLR) has revolutionised our understanding of innate immunity. Numerous reviews have been written on the Subject in the past few years. Here, we review the evidence that TLRs are involved in sensing and initiating anti-viral responses. There are now three strong lines of evidence that support such a role for TLRs. Firstly, TLRs 'recognise' virally derived molecules and are required for various virus-induced cellular effects. Secondly, TLRs trigger anti-viral signalling pathways leading to the induction of the interferon response. Thirdly. viral immuine strategies employed against TLRs have been identitied. (c) 2004 Elsevier Ltd. All rights reserved.
引用
收藏
页码：859 / 867
页数：9
相关论文
共 50 条
  • [41] The role of Toll-like receptors in chronic inflammation
    Drexler, Stefan K.
    Foxwell, Brian M.
    INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 2010, 42 (04) : 506 - 518
  • [42] Role of toll-like receptors in multiple sclerosis
    Miranda-Hernandez, Socorro
    Baxter, Alan G.
    AMERICAN JOURNAL OF CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 2013, 2 (01) : 75 - 93
  • [43] Emerging role of Toll-like receptors in atherosclerosis
    Curtiss, Linda K.
    Tobias, Peter S.
    JOURNAL OF LIPID RESEARCH, 2009, 50 : S340 - S345
  • [44] Toll-like receptors and their role in persistent pain
    Lacagnina, Michael J.
    Watkins, Linda R.
    Grace, Peter M.
    PHARMACOLOGY & THERAPEUTICS, 2018, 184 : 145 - 158
  • [45] Role of toll-like receptors in the development of sepsis
    Tsujimoto, Hironori
    Ono, Satoshi
    Efron, Philip A.
    Scumpia, Philip O.
    Moldawer, Lyle L.
    Mochizuki, Hidetaka
    SHOCK, 2008, 29 (03): : 315 - 321
  • [46] Role of Toll-like receptors in cardiovascular diseases
    Vallejo, Jesus G.
    CLINICAL SCIENCE, 2011, 121 (1-2) : 1 - 10
  • [47] The role of Toll-like receptors in skin diseases
    Bacharewicz, Joanna
    Reduta, Teresa
    Flisiak, Iwona
    PRZEGLAD DERMATOLOGICZNY, 2014, 101 (04): : 309 - 318
  • [48] The Role of Toll-Like Receptors in Pathogenesis of Periodontitis
    Chrzeszczyk, Dariusz
    Konopka, Tomasz
    DENTAL AND MEDICAL PROBLEMS, 2009, 46 (01) : 94 - 103
  • [49] The Role of Toll-Like Receptors in Neuroimmunology of Alcoholism
    Airapetov, M. I.
    Eresko, S. O.
    Lebedev, A. A.
    Bychkov, E. R.
    Shabanov, P. D.
    BIOCHEMISTRY MOSCOW-SUPPLEMENT SERIES B-BIOMEDICAL CHEMISTRY, 2021, 15 (01) : 71 - 79
  • [50] Role of Toll-like receptors in diabetic nephropathy
    Mudaliar, Harshini
    Pollock, Carol
    Panchapakesan, Usha
    CLINICAL SCIENCE, 2014, 126 (9-10) : 685 - 694
12345