The role of Toll-like receptors in the host response to viruses

被引：192
|
作者：
Bowie, AG [1 ]
Haga, IR [1 ]
机构：
[1] Trinity Coll Dublin, Dept Biochem, Dublin 2, Ireland
来源：
MOLECULAR IMMUNOLOGY | 2005年 / 42卷 / 08期
基金：
爱尔兰科学基金会;
关键词：
innate immunity; Toll-like receptors; NF kappa B; IRF3; IFN; virus;
D O I：
10.1016/j.molimm.2004.11.007
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The discovery of Toll-like receptors (TLR) has revolutionised our understanding of innate immunity. Numerous reviews have been written on the Subject in the past few years. Here, we review the evidence that TLRs are involved in sensing and initiating anti-viral responses. There are now three strong lines of evidence that support such a role for TLRs. Firstly, TLRs 'recognise' virally derived molecules and are required for various virus-induced cellular effects. Secondly, TLRs trigger anti-viral signalling pathways leading to the induction of the interferon response. Thirdly. viral immuine strategies employed against TLRs have been identitied. (c) 2004 Elsevier Ltd. All rights reserved.
引用
收藏
页码：859 / 867
页数：9
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