The role of Toll-like receptors in the host response to viruses

被引：192

作者：

Bowie, AG ^{[1
]}

Haga, IR ^{[1
]}

机构：

[1] Trinity Coll Dublin, Dept Biochem, Dublin 2, Ireland

来源：

MOLECULAR IMMUNOLOGY | 2005年 / 42卷 / 08期

基金：

爱尔兰科学基金会;

关键词：

innate immunity; Toll-like receptors; NF kappa B; IRF3; IFN; virus;

D O I：

10.1016/j.molimm.2004.11.007

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The discovery of Toll-like receptors (TLR) has revolutionised our understanding of innate immunity. Numerous reviews have been written on the Subject in the past few years. Here, we review the evidence that TLRs are involved in sensing and initiating anti-viral responses. There are now three strong lines of evidence that support such a role for TLRs. Firstly, TLRs 'recognise' virally derived molecules and are required for various virus-induced cellular effects. Secondly, TLRs trigger anti-viral signalling pathways leading to the induction of the interferon response. Thirdly. viral immuine strategies employed against TLRs have been identitied. (c) 2004 Elsevier Ltd. All rights reserved.

引用

页码：859 / 867

页数：9

共 50 条

[21] Toll-like receptors in health and disease
Wang, Kunyu
Huang, Hanyao
Zhan, Qi
Ding, Haoran
Li, Yi
MEDCOMM, 2024, 5 (05):
[22] Toll-Like Receptors, Their Ligands, and Atherosclerosis
Hodgkinson, Conrad P.
Ye, Shu
THESCIENTIFICWORLDJOURNAL, 2011, 11 : 437 - 453
[23] Toll-like receptors in kidney disease
Smith, Kelly D.
CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION, 2009, 18 (03) : 189 - 196
[24] The role of Toll-like receptors in periodontitis
Song, B.
Zhang, Y. L.
Chen, L. J.
Zhou, T.
Huang, W. K.
Zhou, X.
Shao, L. Q.
ORAL DISEASES, 2017, 23 (02) : 168 - 180
[25] Toll-like receptors in immune response to the viral infections
Mikula, I., Jr.
Pastorekova, S.
Mikula, I., Sr.
ACTA VIROLOGICA, 2010, 54 (04) : 231 - 245
[26] What is the role of Toll-like receptors in bacterial infections?
Gerold, Gisa
Zychlinsky, Arturo
de Diego, Juana L.
SEMINARS IN IMMUNOLOGY, 2007, 19 (01) : 41 - 47
[27] The role of Toll-like receptors in neuropsychiatric disorders: Immunopathology, treatment, and management
Saleki, Kiarash
Alijanizadeh, Parsa
Javanmehr, Nima
Rezaei, Nima
MEDICINAL RESEARCH REVIEWS, 2024, 44 (03) : 1267 - 1325
[28] Role of Toll-Like Receptors in Neuroimmune Diseases: Therapeutic Targets and Problems
Li, Haixia
Liu, Shan
Han, Jinming
Li, Shengxian
Gao, Xiaoyan
Wang, Meng
Zhu, Jie
Jin, Tao
FRONTIERS IN IMMUNOLOGY, 2021, 12
[29] Role of Toll-like receptors in cervical, endometrial and ovarian cancers: A review
Husseinzadeh, Nader
Davenport, Sara Madison
GYNECOLOGIC ONCOLOGY, 2014, 135 (02) : 359 - 363
[30] Toll-like receptors and their role in carcinogenesis and anti-tumor treatment
Wolska, Anna
Lech-Maranda, Ewa
Robak, Tadeusz
CELLULAR & MOLECULAR BIOLOGY LETTERS, 2009, 14 (02) : 248 - 272

← 1 2 3 4 5 →