The role of Toll-like receptors in the host response to viruses

被引：193

作者：

Bowie, AG ^{[1
]}

Haga, IR ^{[1
]}

机构：

[1] Trinity Coll Dublin, Dept Biochem, Dublin 2, Ireland

来源：

MOLECULAR IMMUNOLOGY | 2005年 / 42卷 / 08期

基金：

爱尔兰科学基金会;

关键词：

innate immunity; Toll-like receptors; NF kappa B; IRF3; IFN; virus;

D O I：

10.1016/j.molimm.2004.11.007

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The discovery of Toll-like receptors (TLR) has revolutionised our understanding of innate immunity. Numerous reviews have been written on the Subject in the past few years. Here, we review the evidence that TLRs are involved in sensing and initiating anti-viral responses. There are now three strong lines of evidence that support such a role for TLRs. Firstly, TLRs 'recognise' virally derived molecules and are required for various virus-induced cellular effects. Secondly, TLRs trigger anti-viral signalling pathways leading to the induction of the interferon response. Thirdly. viral immuine strategies employed against TLRs have been identitied. (c) 2004 Elsevier Ltd. All rights reserved.

引用

收藏

页码：859 / 867

页数：9

相关论文

共 76 条

[1]

Ahmad-Nejad P, 2002, EUR J IMMUNOL, V32, P1958, DOI 10.1002/1521-4141(200207)32:7<1958::AID-IMMU1958>3.0.CO

[2]

2-U

[3] Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3 [J].

Alexopoulou, L ;

Holt, AC ;

Medzhitov, R ;

Flavell, RA .

NATURE, 2001, 413 (6857) :732-738

[4] Local delivery of CpG oligodeoxynucleotides induces rapid changes in the genital mucosa and inhibits replication, but not entry, of herpes simplex virus type 2 [J].

Ashkar, AA ;

Bauer, S ;

Mitchell, WJ ;

Vieira, J ;

Rosenthal, KL .

JOURNAL OF VIROLOGY, 2003, 77 (16) :8948-8956

[5] Hemagglutinin protein of wild-type measles virus activates Toll-like receptor 2 signaling [J].

Bieback, K ;

Lien, E ;

Klagge, IM ;

Avota, E ;

Schneider-Schaulies, J ;

Duprex, WP ;

Wagner, H ;

Kirschning, CJ ;

ter Meulen, V ;

Schneider-Schaulies, S .

JOURNAL OF VIROLOGY, 2002, 76 (17) :8729-8736

[6] A46R and A52R from vaccinia virus are antagonists of host IL-1 and toll-like receptor signaling [J].

Bowie, A ;

Kiss-Toth, E ;

Symons, JA ;

Smith, GL ;

Dower, SK ;

O'Neill, LAJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (18) :10162-10167

[7] Cooperation of toll-like receptor 2 and 6 for cellular activation by soluble tuberculosis factor and Borrelia burgdorferi outer surface protein A lipoprotein:: Role of Toll-interacting protein and IL-1 receptor signaling molecules in Toll-like receptor 2 signaling [J].

Bulut, Y ;

Faure, E ;

Thomas, L ;

Equils, O ;

Arditi, M .

JOURNAL OF IMMUNOLOGY, 2001, 167 (02) :987-994

[8] Toll-like receptor 4-dependent activation of dendritic cells by a retrovirus [J].

Burzyn, D ;

Rassa, JC ;

Kim, D ;

Nepomnaschy, I ;

Ross, SR ;

Piazzon, I .

JOURNAL OF VIROLOGY, 2004, 78 (02) :576-584

[9] Human cytomegalovirus activates inflammatory cytokine responses via CD14 and toll-like receptor 2 [J].

Compton, T ;

Kurt-Jones, EA ;

Boehme, KW ;

Belko, J ;

Latz, E ;

Golenbock, DT ;

Finberg, RW .

JOURNAL OF VIROLOGY, 2003, 77 (08) :4588-4596

[10] Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA [J].

Diebold, SS ;

Kaisho, T ;

Hemmi, H ;

Akira, S ;

Sousa, CRE .

SCIENCE, 2004, 303 (5663) :1529-1531

← 1 2 3 4 5 6 7 8 →