Classification and prediction of clinical Alzheimer's diagnosis based on plasma signaling proteins

被引：820

作者：

Ray, Sandip

Britschgi, Markus

Herbert, Charles

Takeda-Uchimura, Yoshiko

Boxer, Adam

Blennow, Kaj

Friedman, Leah F.

Galasko, Douglas R.

Jutel, Marek

Karydas, Anna

Kaye, Jeffrey A.

Leszek, Jerzy

Miller, Bruce L.

Minthon, Lennart

Quinn, Joseph F.

Rabinovici, Gil D.

Robinson, William H.

Sabbagh, Marwan N.

So, Yuen T.

Sparks, D. Larry

Tabaton, Massimo

Tinklenberg, Jared

Yesavage, Jerome A.

Tibshirani, Robert

Wyss-Coray, Tony

机构：

[1] Stanford Univ, Sch Med, Dept Neurol & Neurol Sci, Stanford, CA 94305 USA

[2] Satoris Inc, Redwood City, CA 94063 USA

[3] Memory & Aging Ctr, Dept Neurol, San Francisco, CA 94117 USA

[4] Univ Gothenburg, Sahlgrenska Univ Hosp, Dept Expt Neurosci, Inst Clin Neurosci, S-43180 Molndal, Sweden

[5] Stanford Univ, Sch Med, Dept Psychiat & Behav Sci, Stanford, CA 94305 USA

[6] Univ Calif San Diego, Dept Neurosci, La Jolla, CA 92093 USA

[7] Wroclaw Med Univ, Dept Internal Med & Allergol, PL-50417 Wroclaw, Poland

[8] Oregon Hlth & Sci Univ, Layton Aging & Alzheimers Dis Ctr, Portland, OR 97201 USA

[9] Wroclaw Med Univ, Dept Psychiat, PL-51622 Wroclaw, Poland

[10] Lund Univ, Dept Clin Sci Malmo, Clin Mem Res Unit, Univ Sjukhuset MAS, SE-20502 Malmo, Sweden

[11] Stanford Univ, Sch Med, Div Rheumatol & Immunol, Stanford, CA 94305 USA

[12] Sun Hlth Res Inst, Sun City, AZ 85351 USA

[13] Univ Genoa, Dept Neurosci Ophthalmol & Genet, I-16132 Genoa, Italy

[14] Stanford Univ, Sch Med, Dept Hlth Res & Policy, Stanford, CA 94305 USA

[15] Vet Affairs Palo Alto Hlth Care Syst, Ctr Geriatr Res Educ & Clin, Palo Alto, CA 94304 USA

来源：

NATURE MEDICINE | 2007年 / 13卷 / 11期

关键词：

D O I：

10.1038/nm1653

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A molecular test for Alzheimer's disease could lead to better treatment and therapies. We found 18 signaling proteins in blood plasma that can be used to classify blinded samples from Alzheimer's and control subjects with close to 90% accuracy and to identify patients who had mild cognitive impairment that progressed to Alzheimer's disease 2-6 years later. Biological analysis of the 18 proteins points to systemic dysregulation of hematopoiesis, immune responses, apoptosis and neuronal support in presymptomatic Alzheimer's disease.

引用

页码：1359 / 1362

页数：4

共 15 条

[1] Plasma levels of amyloid β-protein 42 are increased in women with mild cognitive impairment [J].