NIR-II Organic Nanotheranostics for Precision Oncotherapy

被引：101

作者：

Dai, Hanming ^{[1
,2
]}

Wang, Xiaorui ^{[1
,2
]}

Shao, Jinjun ^{[1
,2
]}

Wang, Wenjun ^{[3
]}

Mou, Xiaozhou ^{[4
]}

Dong, Xiaochen ^{[1
,2
]}

机构：

[1] Nanjing Tech Univ NanjingTech, Key Lab Flexible Elect KLOFE, Nanjing 211816, Peoples R China

[2] Nanjing Tech Univ NanjingTech, Inst Adv Mat IAM, Nanjing 211816, Peoples R China

[3] Liaocheng Univ, Sch Phys Sci & Informat Technol, Liaocheng 252059, Shandong, Peoples R China

[4] Zhejiang Prov Peoples Hosp, Hangzhou Med Coll, Affiliated Peoples Hosp, Clin Res Inst, Hangzhou 310014, Peoples R China

来源：

SMALL | 2021年 / 17卷 / 44期

关键词：

organic nanotheranostics; precision oncotherapy; second near-infrared; SEMICONDUCTING POLYMER NANOPARTICLES; INTRAMOLECULAR CHARGE-TRANSFER; NEAR-INFRARED WINDOW; PHOTOTHERMAL THERAPY; CONJUGATED POLYMER; RATIONAL DESIGN; RECENT PROGRESS; GAS THERAPY; FLUORESCENCE; CANCER;

D O I：

10.1002/smll.202102646

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Precision oncotherapy can remove tumors without causing any apparent iatrogenic damage or irreversible side effects to normal tissues. Second near-infrared (NIR-II) nanotheranostics can simultaneously perform diagnostic and therapeutic modalities in a single nanoplatform, which exhibits prominent perspectives in tumor precision treatment. Among all NIR-II nanotheranostics, NIR-II organic nanotheranostics have shown an exceptional promise for translation in clinical tumor treatment than NIR-II inorganic nanotheranostics in virtue of their good biocompatibility, excellent reproducibility, desirable excretion, and high biosafety. In this review, recent progress of NIR-II organic nanotheranostics with the integration of tumor diagnosis and therapy is systematically summarized, focusing on the theranostic modes and performances. Furthermore, the current status quo, problems, and challenges are discussed, aiming to provide a certain guiding significance for the future development of NIR-II organic nanotheranostics for precision oncotherapy.

引用

页数：23

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