Death squads enlisted by the tumour suppressor p53

被引：97
作者：
Michalak, E
Villunger, A
Erlacher, M
Strasser, A [1 ]
机构：
[1] Walter & Eliza Hall Inst Med Res, Melbourne, Vic 3050, Australia
[2] Innsbruck Med Univ, Bioctr, Div Pathophysiol, Innsbruck, Austria
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2005年 / 331卷 / 03期
基金：
美国国家卫生研究院; 英国医学研究理事会; 奥地利科学基金会;
关键词：
apoptosis; p53; cancer; PUMA; Noxa; BCL-2;
D O I：
10.1016/j.bbrc.2005.03.183
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
p53 is a tumour suppressor that is found mutated or functionally inactivated in more than half of all human cancers. p53 function is activated by DNA damage, hypoxia, expression of certain oncogenes, and many cytotoxic stimuli. p53 is a transcription factor that regulates expression of target genes which promote apoptotic cell death, cell cycle arrest.. cellular senescence, and some other processes. In this review we summarise current knowledge of p53 target genes implicated in apoptosis signalling. (c) 2005 Elsevier Inc. All rights reserved.
引用
收藏
页码：786 / 798
页数：13
相关论文
共 138 条
  • [41] The E1B 19K protein blocks apoptosis by interacting with and inhibiting the p53-inducible and death-promoting Bax protein
    Han, JH
    Sabbatini, P
    Perez, D
    Rao, L
    Modha, D
    White, E
    [J]. GENES & DEVELOPMENT, 1996, 10 (04) : 461 - 477
  • [42] Expression of bbc3, a pro-apoptotic BH3-only gene, is regulated by diverse cell death and survival signals
    Han, JW
    Flemington, C
    Houghton, AB
    Gu, ZM
    Zambetti, GP
    Lutz, RJ
    Zhu, L
    Chittenden, T
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (20) : 11318 - 11323
  • [43] Suppression of tumorigenesis by the p53 target PUMA
    Hemann, MT
    Zilfou, JT
    Zhao, Z
    Burgess, DJ
    Hannon, GJ
    Lowe, SW
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (25) : 9333 - 9338
  • [44] HOFERWARBINEK R, 2004, CELL DEATH DIFFER
  • [45] BH3-Only proteins - Essential initiators of apoptotic cell death
    Huang, DCS
    Strasser, A
    [J]. CELL, 2000, 103 (06) : 839 - 842
  • [46] Ferredoxin reductase affects p53-dependent, 5-fluorouracil-induced apoptosis in colorectal cancer cells
    Hwang, PM
    Bunz, F
    Yu, J
    Rago, C
    Chan, TA
    Murphy, MP
    Kelso, GF
    Smith, RAJ
    Kinzler, KW
    Vogelstein, B
    [J]. NATURE MEDICINE, 2001, 7 (10) : 1111 - 1117
  • [47] Perp is a mediator of p53-dependent apoptosis in diverse cell types
    Ihrie, RA
    Reczek, E
    Horner, JS
    Khachatrian, L
    Sage, J
    Jacks, T
    Attardi, LD
    [J]. CURRENT BIOLOGY, 2003, 13 (22) : 1985 - 1990
  • [48] TUMOR SPECTRUM ANALYSIS IN P53-MUTANT MICE
    JACKS, T
    REMINGTON, L
    WILLIAMS, BO
    SCHMITT, EM
    HALACHMI, S
    BRONSON, RT
    WEINBERG, RA
    [J]. CURRENT BIOLOGY, 1994, 4 (01) : 1 - 7
  • [49] Noxa in colorectal cancer:: a study on DNA, mRNA and protein expression
    Jansson, AK
    Emterling, AM
    Arbman, G
    Sun, XF
    [J]. ONCOGENE, 2003, 22 (30) : 4675 - 4678
  • [50] Inactivation of p21WAF1 sensitizes cells to apoptosis via an increase of both p14ARF and p53 levels and an alteration of the Bax/Bcl-2 ratio
    Javelaud, D
    Besançon, F
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (40) : 37949 - 37954
12345678910