Meta-Analysis of EMT Datasets Reveals Different Types of EMT

被引:25
作者
Liang, Lining [1 ]
Sun, Hao [1 ]
Zhang, Wei [2 ]
Zhang, Mengdan [1 ]
Yang, Xiao [1 ]
Kuang, Rui [2 ]
Zheng, Hui [1 ]
机构
[1] Chinese Acad Sci, Guangzhou Inst Biomed & Hlth, CAS Key Lab Regenerat Biol, Guangdong Prov Key Lab Stem Cell & Regenerat Med, Guangzhou, Guangdong, Peoples R China
[2] Univ Minnesota Twin Cities, Dept Comp Sci & Engn, Minneapolis, MN USA
来源
PLOS ONE | 2016年 / 11卷 / 06期
基金
美国国家科学基金会; 中国国家自然科学基金;
关键词
TO-MESENCHYMAL TRANSITION; CELL-ADHESION MOLECULES; DIRECT CONVERSION; STEM-CELLS; EPITHELIAL TRANSITION; SIGNALING PATHWAY; NEURONAL CELLS; RETINOIC ACID; CANCER; FIBROBLASTS;
D O I
10.1371/journal.pone.0156839
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
As a critical process during embryonic development, cancer progression and cell fate conversions, epithelial-mesenchymal transition (EMT) has been extensively studied over the last several decades. To further understand the nature of EMT, we performed meta-analysis of multiple microarray datasets to identify the related generic signature. In this study, 24 human and 17 mouse microarray datasets were integrated to identify conserved gene expression changes in different types of EMT. Our integrative analysis revealed that there is low agreement among the list of the identified signature genes and three other lists in previous studies. Since removing the datasets with weakly-induced EMT from the analysis did not significantly improve the overlapping in the signature-gene lists, we hypothesized the existence of different types of EMT. This hypothesis was further supported by the grouping of 74 human EMT-induction samples into five distinct clusters, and the identification of distinct pathways in these different clusters of EMT samples. The five clusters of EMT-induction samples also improves the understanding of the characteristics of different EMT types. Therefore, we concluded the existence of different types of EMT was the possible reason for its complex role in multiple biological processes.
引用
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页数:22
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