Effects of leukoreduction on N-methylhistamine concentration in stored units of canine whole blood

被引:0
|
作者
Frank, Mariah J. [1 ]
Khattab, Mohammad R. [4 ]
Wills, Robert W. [2 ]
Archer, Todd M. [3 ]
Mackin, Andrew J. [3 ]
Suchodolski, Jan S. [4 ]
Lidbury, Jonathan A. [4 ]
Steiner, Joerg M. [4 ]
Sullivant, Alyssa M. [3 ]
Thomason, John M. [3 ]
机构
[1] Atlantic Vet Internal Med & Oncol Hosp, Towson, MD 21286 USA
[2] Mississippi State Univ, Coll Vet Med, Dept Comparat Biomed Sci, Mississippi State, MS 39762 USA
[3] Mississippi State Univ, Coll Vet Med, Dept Clin Sci, Mississippi State, MS 39762 USA
[4] Texas A&M Univ, Coll Vet Med & Biomed Sci, Gastrointestinal Lab, Dept Small Anim Clin Sci, College Stn, TX 77843 USA
关键词
PLASMA HISTAMINE LEVELS; CELL TRANSFUSIONS; STORAGE; EXPRESSION; RELEASE; URINE; TIME; DOGS;
D O I
暂无
中图分类号
S85 [动物医学(兽医学)];
学科分类号
0906 ;
摘要
OBJECTIVE To determine the effects of leukoreduction on N-methylhistamine ( NMH; a stable histamine metabolite) concentration in units of canine whole blood during storage and incubation at room temperature ( approx 22 degrees C) to simulate temperature conditions during transfusion. ANIMALS 8 healthy adult Walker Hounds. PROCEDURES A standard unit of blood (450 mL) was obtained from each dog twice, with at least 28 days between donations. Blood units collected from 4 dogs during the first donation underwent leukoreduction, whereas the blood units collected from the other 4 dogs did not undergo leukoreduction, prior to storage at 4 degrees C. The alternate treatment was applied to blood units collected during the second donation. A sample from each unit was obtained for determination of plasma NMH concentration the day of donation (before and after leukoreduction when applicable) and before and after incubation at room temperature for 5 hours on days 14 and 28 of storage. RESULTS Units that underwent leukoreduction had substantially lower leukocyte and platelet counts than nonleukoreduced units. Plasma NMH concentration increased immediately after leukoreduction but did not change significantly during the subsequent 28 days of storage, nor did it differ between units that did and did not undergo leukoreduction. CONCLUSIONS AND CLINICAL RELEVANCE Leukoreduction and simulated transfusion temperature did not affect the histamine load in units of canine whole blood during the first 28 days of storage. Further research is necessary to determine whether histamine contributes to the development and severity of blood transfusion reactions in dogs.
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页码:890 / 896
页数:7
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