Metal complexes of 4-amino-N-(2-pyrimidinyl)benzene sulfonamide: Synthesis, characterization and Antiprotozoal studies

We present the synthesis, characterization and in vitro anti-protozoal studies of Cu(II), Zn(II), Mn(II), Ni(II), Pd(II), Pt(II), and VO(II) complexes of sulfadiazine. Elemental analysis, IR, UV-Vis, room temperature magnetic moments were used to characterize the complexes. Cu(II), Zn(II), Mn(II), Ni(II), and VO(II) formed octahedral complexes formulated as [M(SD)(2)(H2O)(2)]. xH(2)O, (SD = sulfadiazine), while Pd(II) and Pt(II) formed square planar complexes containing one molecule of sulfadiazine. In all the complexes, the sulfadiazine acts as a bidentate ligand coordinating through the sulfonamido N-atom and the pyrimidinic N-atom. The complexes were screened against the resistant strains of Plasmodium falciparum, T.b. rhodosiense and L. donovani to determine their antiprotozoal activities.