A new, efficient, and inexpensive copper(II)/salicylic acid complex catalyzed Sonogashira-type cross-coupling of haloarenes and iodoheteroarenes with terminal alkynes

被引：53

作者：

Chen, Horung-Jyh ^{[1
]}

Lin, Zhe-Yi ^{[1
]}

Li, Meng-Yuan ^{[1
]}

Lian, Ruei-Jheng ^{[1
]}

Xue, Qing-Wen ^{[1
]}

Chung, Jui-Lun ^{[1
]}

Chen, Shu-Chih ^{[1
]}

Chen, Yao-Jung ^{[1
]}

机构：

[1] Natl Chung Hsing Univ, Dept Chem, Taichung 402, Taiwan

来源：

TETRAHEDRON | 2010年 / 66卷 / 39期

关键词：

Salicylic acid; Sonogashira-type cross-coupling reaction; Copper chloride; Haloarenes; Terminal alkynes; IRON/COPPER COCATALYZED ALKYNYLATION; RAY CRYSTAL-STRUCTURES; EARTH METAL-IONS; COPPER-FREE; ARYL BROMIDES; LIGAND-FREE; AMINE-FREE; PALLADIUM-FREE; CHEMISTRY; HALIDES;

D O I：

10.1016/j.tet.2010.07.072

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new, efficient, and inexpensive CuCl2/salicylic acid catalytic system has been developed to catalyze Sonogashira-type cross-coupling of haloarenes and iodoheteroarenes with terminal alkynes under mild reaction conditions to afford the corresponding coupling products in 18-95% yields. The role of salicylic acid might act as a bidentate O,O-donor ligand to activate the catalytic reactivity of copper chloride in coupling reactions was also briefly discussed. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：7755 / 7761

页数：7

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