Co-precipitation of mefenamic acid-polyvinylpyrrolidone K30 composites using Gas Anti-Solvent

被引：11
作者：
Dittanet, Peerapan [1 ]
Phothipanyakun, Sasiwimon [1 ]
Charoenchaitrakool, Manop [1 ,2 ]
机构：
[1] Kasetsart Univ, Fac Engn, Dept Chem Engn, Bangkok 10900, Thailand
[2] Kasetsart Univ, Ctr Adv Studies Nanotechnol & Its Applicat Chem F, Bangkok 10900, Thailand
来源：
JOURNAL OF THE TAIWAN INSTITUTE OF CHEMICAL ENGINEERS | 2016年 / 63卷
关键词：
GAS process; Mefenamic acid; PVP; Composite materials; DISSOLUTION RATE ENHANCEMENT; SOLID DISPERSIONS; RAPID EXPANSION; MICRONIZATION; MICROPARTICLES; IMPREGNATION; POLYMORPHS; KETOPROFEN;
D O I：
10.1016/j.jtice.2016.03.010
中图分类号：
TQ [化学工业];
学科分类号：
0817 ;
摘要：
In this study, composites of mefenamic acid (MEF) and polyvinylpyrrolidone K30 (PVP K30, MW similar to 40,000) were synthesized by applying the Gas Anti-Solvent (GAS) technique. It was found that an increase in drug-to-polymer ratio resulted in a higher % drug content. However, temperature and solution concentration had no significant effect on the % drug content when the amount, of polymer in the solution was lower than or equal to that of the drug. The dissolution rate of the MEF PVP composites was found to be 7 times and 3 times greater than those of the unprocessed MEF and physical mixture, respectively. (c) 2016 Taiwan Institute of Chemical Engineers. Published by Elsevier B.V. All rights reserved.
引用
收藏
页码：17 / 24
页数：8
相关论文
共 26 条
  • [1] Supercritical solvent impregnation of piroxicam on PVP at various polymer molecular weights
    Banchero, Mauro
    Manna, Luigi
    Ronchetti, Silvia
    Campanelli, Pasquale
    Ferri, Ada
    [J]. JOURNAL OF SUPERCRITICAL FLUIDS, 2009, 49 (02) : 271 - 278
  • [2] Micronization of aztreonam with supercritical anti-solvent process
    Chang, Shan-Chun
    Hsu, Tien-Hao
    Chu, Yu-Heng
    Lin, Ho-mu
    Lee, Ming-Jer
    [J]. JOURNAL OF THE TAIWAN INSTITUTE OF CHEMICAL ENGINEERS, 2012, 43 (05) : 790 - 797
  • [3] Micronization by rapid expansion of supercritical solutions to enhance the dissolution rates of poorly water-soluble pharmaceuticals
    Charoenchaitrakool, M
    Dehghani, F
    Foster, NR
    Chan, HK
    [J]. INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH, 2000, 39 (12) : 4794 - 4802
  • [4] Charoenchaitrakool M, 2013, CHIANG MAI J SCI, V40, P440
  • [5] Production of theophylline and polyethylene glycol 4000 composites using Gas Anti-Solvent (GAS) process
    Charoenchaitrakool, Manop
    Polchiangdee, Chotchuang
    Srinophakun, Penjit
    [J]. MATERIALS LETTERS, 2009, 63 (01) : 136 - 138
  • [6] Preparation of acetazolamide composite microparticles by supercritical anti-solvent techniques
    Duarte, Ana Rita C.
    Roy, Christelle
    Vega-Gonzalez, Arlette
    Duarte, Catarina M. M.
    Subra-Patemault, Pascale
    [J]. INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2007, 332 (1-2) : 132 - 139
  • [7] Dissolution rate enhancement of loratadine in polyvinylpyrrolidone K-30 solid dispersions by solvent methods
    Frizon, Fernando
    Eloy, Josimar de Oliveira
    Donaduzzi, Carmen Maria
    Mitsui, Marcia Lina
    Marchetti, Juliana Maldonado
    [J]. POWDER TECHNOLOGY, 2013, 235 : 532 - 539
  • [8] Infrared studies of the thermal conversion of mefenamic acid between polymorphic states
    Gilpin, RK
    Zhou, W
    [J]. VIBRATIONAL SPECTROSCOPY, 2005, 37 (01) : 53 - 59
  • [9] Micronization of drug particles via RESS process
    Hezave, Ali Zeinolabedini
    Esmaeilzadeh, Feridun
    [J]. JOURNAL OF SUPERCRITICAL FLUIDS, 2010, 52 (01) : 84 - 98
  • [10] Micronization of fenofibrate by rapid expansion of supercritical solution
    Hiendrawan, Stevanus
    Veriansyah, Bambang
    Tjandrawinata, Raymond R.
    [J]. JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY, 2014, 20 (01) : 54 - 60
123