Unresolved questions concerning human papillomavirus infection and transmission: a modelling perspective

被引:6
作者
Regan, David G. [1 ]
Philp, David J. [2 ]
Waters, Edward K. [1 ]
机构
[1] Univ New S Wales, Natl Ctr HIV Epidemiol & Clin Res, Coogee, NSW 2034, Australia
[2] Univ New S Wales, Sch Publ Hlth & Community Med, Sydney, NSW 2052, Australia
基金
澳大利亚研究理事会;
关键词
dynamic model; infectiousness; knowledge gaps; mathematical transmission model; vaccination; CERVICAL INTRAEPITHELIAL NEOPLASIA; SEXUALLY-TRANSMITTED-DISEASES; RISK HUMAN-PAPILLOMAVIRUS; POPULATION-LEVEL IMPACT; USE PROMOTES REGRESSION; NONVACCINE HPV TYPES; MALE CIRCUMCISION; COST-EFFECTIVENESS; CONDOM USE; MESSENGER-RNA;
D O I
10.1071/SH10006
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
Mathematical transmission models are widely used to forecast the potential impact of interventions such as vaccination and to inform the development of health policy. Effective vaccines are now available for the prevention of cervical cancer and other diseases attributable to human papillomavirus (HPV). Considerable uncertainties remain regarding the characterisation of HPV infection and its sequelae, infectivity, and both vaccine-conferred and naturally-acquired immunity. In this review, we discuss the key knowledge gaps that impact on our ability to develop accurate models of HPV transmission and vaccination.
引用
收藏
页码:368 / 375
页数:8
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