Comparison of Outcomes Between Repeated and a Single Dose of Mifepristone in Combination with Misoprostol for Abortion: a Retrospective Cohort Study

被引：0
|
作者：
Shi, Beibei [1 ]
Zhu, Xuejie [1 ]
Wang, Hanchu [1 ]
Zhu, Fangfang [1 ]
机构：
[1] Wenzhou Med Univ, Affiliated Hosp 1, Dept Obstet & Gynecol, Wenzhou 325035, Peoples R China
来源：
LATIN AMERICAN JOURNAL OF PHARMACY | 2018年 / 37卷 / 07期
关键词：
drug dose; early abortion; medical abortion; mifepristone; MEDICAL ABORTION; EARLY-PREGNANCY; TERMINATION; MG;
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
This study is aimed to compare the effectiveness and safety of repeated doses and a single dose of mifepristone in combination with misoprostol for abortion less than 49 days' gestation. The complete abortion rate was 91.72% in the 145 women treated with 150 mg mifepristone in divided times (Group A) and 92.47% in the 146 women treated with 100 mg mifepristone once (Group B) (P > 0.05). The frequency of nausea, vomiting, dizziness and headache was similar between the two groups. However, we observed that the average length of bleeding days in Group B (4.15 +/- 1.28) was much shorter than that in Group A (7.54 +/- 1.94; P < 0.01), the rate of abdominal pain in Group A was much lower than that in Group B (P < 0.05), and the very satisfaction rate was significantly higher in Group B (P < 0.05).
引用
收藏
页码：1383 / 1387
页数：5
相关论文
共 50 条
  • [1] A prospective study on the effectiveness of a combination regime (Mifepristone and Misoprostol) in comparison with Misoprostol for missed abortion
    Gupta, Nidhi
    Tripathi, Reva
    Sharma, Sumedha
    Nigam, Aruna
    Panesar, Sanjeet
    JOURNAL OF FAMILY MEDICINE AND PRIMARY CARE, 2023, 12 (10) : 2423 - 2427
  • [2] EARLY ABORTION INDUCTION BY A COMBINATION OF MIFEPRISTONE AND ORAL MISOPROSTOL - A COMPARISON BETWEEN 2 DOSE REGIMENS OF MISOPROSTOL AND THEIR EFFECT ON BLOOD-PRESSURE
    ELREFAEY, H
    TEMPLETON, A
    BRITISH JOURNAL OF OBSTETRICS AND GYNAECOLOGY, 1994, 101 (09): : 792 - 796
  • [3] Evaluation of shorter mifepristone to misoprostol intervals for second trimester medical abortion: a retrospective cohort study
    Henkel, Andrea
    Lerma, Klaira
    Blumenthal, Paul D.
    Shaw, Kate A.
    CONTRACEPTION, 2020, 102 (05) : 327 - 331
  • [4] RANDOMIZED TRIAL OF MISOPROSTOL AND CERVAGEM IN COMBINATION WITH A REDUCED DOSE OF MIFEPRISTONE FOR INDUCTION OF ABORTION
    BAIRD, DT
    SUKCHAROEN, N
    THONG, KJ
    HUMAN REPRODUCTION, 1995, 10 (06) : 1521 - 1527
  • [5] INDUCTION OF ABORTION IN THE 2ND TRIMESTER BY A COMBINATION OF MISOPROSTOL AND MIFEPRISTONE - A RANDOMIZED COMPARISON BETWEEN 2 MISOPROSTOL REGIMENS
    ELREFAEY, H
    TEMPLETON, A
    HUMAN REPRODUCTION, 1995, 10 (02) : 475 - 478
  • [6] Comparative study between single dose 600 μg and repeated dose of oral misoprostol for treatment of incomplete abortion
    Phupong, V
    Taneepanichskul, S
    Kriengsinyot, R
    Sriyirojana, N
    Blanchard, K
    Winikoff, B
    CONTRACEPTION, 2004, 70 (04) : 307 - 311
  • [7] PREGNANCY TERMINATION WITH MIFEPRISTONE AND GEMEPROST - A MULTICENTER COMPARISON BETWEEN REPEATED DOSES AND A SINGLE DOSE OF MIFEPRISTONE
    VANLOOK, PFA
    FERTILITY AND STERILITY, 1991, 56 (01) : 32 - 40
  • [8] Comparison of two doses of mifepristone in combination with misoprostol for early medical abortion:: a randomised trial
    Wu, YM
    Gomez-Alzugaray, M
    Haukkamaa, M
    Ngoc, NTN
    Ho, PC
    Pretnar-Darovec, A
    Healy, DL
    Sotnikova, E
    Shah, RS
    Pavlova, NG
    Chen, JK
    Song, S
    Bygdeman, M
    Kovács, L
    Khomassuridze, A
    Song, LJ
    Hamzaoui, R
    Alexaniants, S
    Van Look, PFA
    von Hertzen, H
    Piaggio, G
    Peregoudov, A
    Vucurevic, M
    Grimes, D
    BRITISH JOURNAL OF OBSTETRICS AND GYNAECOLOGY, 2000, 107 (04): : 524 - 530
  • [9] Early medical abortion with self-administered low-dose mifepristone in combination with misoprostol
    Song, Li-Ping
    Tang, Shi-Yan
    Li, Cui-Lan
    Zhou, Lee-Jaden-Gil-Yu-Kang
    Mo, Xue-Tang
    JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH, 2018, 44 (09) : 1705 - 1711
  • [10] A randomised study of misoprostol and gemeprost in combination with mifepristone for induction of abortion in the second trimester of pregnancy
    Bartley, J
    Baird, DT
    BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY, 2002, 109 (11) : 1290 - 1294
12345