A tarantula peptide against pain via ASIC1a channels and opioid mechanisms

被引：202

作者：

Mazzuca, Michel

Heurteaux, Catherine

Alloui, Abdelkrim

Diochot, Sylvie

Baron, Anne

Voilley, Nicolas

Blondeau, Nicolas

Escoubas, Pierre

Gelot, Agnes

Cupo, Anny

Zimmer, Andreas

Zimmer, Anne M.

Eschalier, Alain

Lazdunski, Michel

机构：

[1] Univ Nice Sophia Antipolis, Inst Pharmacol Mol & Cellulaire, CNRS, Inst Paul Hamel, F-06560 Valbonne, France

[2] CHU, Fac Med, INSERM, Unite Mixte Rech 766, Clermont Ferrand, France

[3] Univ Bonn, Dept Mol Psychiat, D-53105 Bonn, Germany

来源：

NATURE NEUROSCIENCE | 2007年 / 10卷 / 08期

关键词：

D O I：

10.1038/nn1940

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Psalmotoxin 1, a peptide extracted from the South American tarantula Psalmopoeus cambridgei, has very potent analgesic properties against thermal, mechanical, chemical, inflammatory and neuropathic pain in rodents. It exerts its action by blocking acid-sensing ion channel 1a, and this blockade results in an activation of the endogenous enkephalin pathway. The analgesic properties of the peptide are suppressed by antagonists of the mu and delta-opioid receptors and are lost in Penk1(-/-) mice.

引用

页码：943 / 945

页数：3

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