Gelsedine-type oxindole alkaloids from Gelsemium elegans and the evaluation of their cytotoxic activity

被引：15

作者：

Wang, Lei ^{[1
]}

Wang, Jin-Feng ^{[2
]}

Mao, Xia ^{[3
]}

Jiao, Li ^{[4
]}

Wang, Xiao-Jun ^{[5
]}

机构：

[1] Jilin Univ, Stomatol Hosp, Periodontal Dept, Changchun 130021, Jilin, Peoples R China

[2] Jilin Univ, Hosp 2, Dermatol Dept, Changchun 130041, Jilin, Peoples R China

[3] Qujing Normal Univ, Coll Biol Resources & Environm Sci, Qujing 655011, Peoples R China

[4] Bethune Mil Med Acad, Dept Physiol, Shijiashuang 050061, Peoples R China

[5] Jilin Univ, Hosp 2, Thorac Dept, Changchun 130041, Jilin, Peoples R China

来源：

FITOTERAPIA | 2017年 / 120卷

关键词：

Gelsemium elegans; Loganiaceae; Alkaloids; Cytotoxicity; MONOTERPENOID INDOLE ALKALOIDS; BENTH;

D O I：

10.1016/j.fitote.2017.06.005

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Phytochemical investigation on the 70% EtOH extract of the leaves and branches of Gelsemium elegans resulted into the isolation of five new gelsedine-type oxindole alkaloids, gelseleganins A-E (1-5). The structures of the isolated compounds were established based on 1D and 2D (H-1 center dot H-1 COSY, HMQC, and HMBC) NMR spectroscopy, in addition to high resolution mass spectrometry. The isolated alkaloids were tested in vitro for cytotoxic potential against seven tumor cell lines. As a result, alkaloids 3 exhibited significant cytotoxic activities against all the tested tumor cell lines with IC50 values < 10 mu M.

引用

页码：131 / 135

页数：5

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