Association of rs10757274 and rs2383206 Polymorphisms on 9p21 locus with Coronary Artery Disease in Turkish Population

被引：7

作者：

Yayla, Cagri ^{[1
]}

Okyay, Kaan ^{[2
]}

Yilmaz, Akin ^{[3
]}

Sahinarslan, Asife ^{[1
]}

Saglam, Atiye Seda Yar ^{[3
]}

Eyiol, Azmi ^{[1
]}

Bolayir, Hasan Ata ^{[1
]}

Sezenoz, Burak ^{[1
]}

Menevse, Sevda ^{[3
]}

Cengel, Atiye ^{[1
]}

机构：

[1] Gazi Univ, Dept Cardiol, Sch Med, Ankara, Turkey

[2] Baskent Univ, Dept Cardiol, Sch Med, Ankara, Turkey

[3] Gazi Univ, Dept Med Biol & Genet, Sch Med, Ankara, Turkey

来源：

KOREAN CIRCULATION JOURNAL | 2016年 / 46卷 / 05期

关键词：

Genetics; Atherosclerosis; Polymorphism; MYOCARDIAL-INFARCTION; COMMON VARIANT; ATHEROSCLEROSIS; RISK; REPLICATION; SEVERITY; ANRIL; GENE;

D O I：

10.4070/kcj.2016.46.5.615

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background and Objectives: Genetic predisposition is an important risk factor for coronary artery disease (CAD). In this study, we aimed to evaluate the impact of rs10757274 and rs2383206 polymorphisms in chromosome 9p21 on presence and severity of CAD in a Turkish population. Subjects and Methods: A total of 646 patients who underwent coronary angiography were included in this study. Coronary vessel score and Gensini score were calculated to assess the angiographic severity of CAD. Alleles of AA, AG, and GG were determined for rs10757274 (polymorphism-1) and rs2383206 (polymorphism-2) polymorphisms located in chromosome 9p21 from the blood samples. Results: There was a significant difference between the alleles in polymorphism-1 in the presence of coronary artery disease (38.9% in AA, 48.0% in GG and 56.4% in AG, p=0.017). However, there was no difference between the alleles in polymorphism-2. According to vessel scores, there was a significant difference between the alleles in polymorphism-1 (AA 0.71 +/- 1.04, GG 0.88 +/- 1.07, AG 1.06 +/- 1.12, p=0.018). In polymorphism-2, vessel scores did not show a difference between the alleles. In polymorphism-1, there was a significant difference in Gensini score (p=0.041). Gensini scores did not differ between the alleles in polymorphism-2 (p>0.05 for all). In multivariate analyses, none of the alleles was an independent factor for presence of CAD. Conclusion: The presence of rs10757274 polymorphism including AG allele in chromosome 9p21 was related to CAD. However, this relationship was not independent of other cardiovascular risk factors.

引用

页码：615 / 621

页数：7