microRNAs in cancer management

被引：711

作者：

Kong, Yi W.

Ferland-McCollough, David

Jackson, Thomas J. ^{[2
]}

Bushell, Martin ^{[1
]}

机构：

[1] MRC, Toxicol Unit, Med Res Council, Leicester LE1 9HN, Leics, England

[2] Univ Nottingham, Sch Med, Queens Med Ctr, Nottingham NG7 2RD, England

来源：

LANCET ONCOLOGY | 2012年 / 13卷 / 06期

基金：

英国生物技术与生命科学研究理事会; 英国医学研究理事会;

关键词：

GENE-EXPRESSION; BREAST-CANCER; CIRCULATING MICRORNAS; MESENCHYMAL TRANSITION; CELL-PROLIFERATION; DOWN-REGULATION; LUNG-CANCER; STEM-CELLS; TUMOR; BIOMARKERS;

D O I：

10.1016/S1470-2045(12)70073-6

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Since the identification of microRNAs (miRNAs) in 1993, and the subsequent discovery of their highly conserved nature in 2000, the amount of research into their function-particularly how they contribute to malignancy-has greatly increased. This class of small RNA molecules control gene expression and provide a previously unknown control mechanism for protein synthesis. As such, it is unsurprising that miRNAs are now known to play an essential part in malignancy, functioning as tumour suppressors and oncogenes. This Review summarises the present understanding of how miRNAs operate at the molecular level; how their dysregulation is a crucial part of tumour formation, maintenance, and metastasis; how they can be used as biomarkers for disease type and grade; and how miRNA-based treatments could be used for diverse types of malignancies.

引用

页码：E249 / E258

页数：10

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