New Mechanisms of Tumor-Associated Macrophages on Promoting Tumor Progression: Recent Research Advances and Potential Targets for Tumor Immunotherapy

被引：106

作者：

Guo, Qiujun ^{[1
,2
]}

Jin, Zhichao ^{[1
]}

Yuan, Yuan ^{[1
,2
]}

Liu, Rui ^{[1
]}

Xu, Tao ^{[3
]}

Wei, Huamin ^{[1
]}

Xu, Xinyao ^{[1
,2
]}

He, Shulin ^{[1
,2
]}

Chen, Shuntai ^{[1
,2
]}

Shi, Zhan ^{[4
]}

Hou, Wei ^{[1
]}

Hua, Baojin ^{[1
]}

机构：

[1] China Acad Chinese Med Sci, Guanganmen Hosp, Dept Oncol, 5 Beixiange, Beijing 100053, Peoples R China

[2] Beijing Univ Chinese Med, 11 North Third Ring Rd East, Beijing 100029, Peoples R China

[3] China Acad Chinese Med Sci, Xiyuan Hosp, Dept Oncol, 1 Playground Rd, Beijing 100091, Peoples R China

[4] China Acad Chinese Med Sci, Inst Basic Res Clin Med IBRCM, 16 Dongzhimen Nanxiaojie, Beijing 100700, Peoples R China

来源：

JOURNAL OF IMMUNOLOGY RESEARCH | 2016年 / 2016卷

基金：

中国国家自然科学基金;

关键词：

LYMPHATIC MICROVESSEL DENSITY; COLONY-STIMULATING FACTOR; CANCER STEM-CELLS; EPITHELIAL-MESENCHYMAL TRANSITION; INFILTRATING MYELOID CELLS; BREAST-CANCER; POOR-PROGNOSIS; LUNG-CANCER; INTERFERON-GAMMA; GROWTH-FACTORS;

D O I：

10.1155/2016/9720912

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The majority of basic and clinical studies have shown a protumor function of tumor-associated macrophages (TAMs), which represent a large proportion of matrix cells. TAMs promote tumorigenesis, and their number is related to the malignancy degree and poor prognosis of many kinds of tumors. Macrophage plasticity makes it possible to change the tumor microenvironment and remodel antitumor immunity during cancer immunotherapy. Increasing numbers of studies have revealed the effects of TAMs on the tumor microenvironment, for example, via promotion of tumor growth and tumorigenesis and through an increase in the number of cancer stem cells or via facilitation of angiogenesis, lymphangiogenesis, and metastasis. Investigators also proposed tumor-immunological treatments targeting TAMs by inhibiting TAM recruitment and differentiation, by regulating TAM polarization, and by blocking factors and pathways associated with the protumor function of TAMs. This comprehensive review presents recent research on TAMs in relation to prediction of poor outcomes, remodeling of the tumor immune microenvironment, and immunological targeted therapies.

引用

页数：12

共 138 条

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