Microfluidic blood/plasma separation unit based on microchannel bend structures

被引：12

作者：

Blattert, C ^{[1
]}

Jurischka, R ^{[1
]}

Tahhan, I ^{[1
]}

Schoth, A ^{[1
]}

Kerth, P ^{[1
]}

Menz, W ^{[1
]}

机构：

[1] Univ Freiburg, Lab Proc Technol, IMTEK, Inst Microsyst Technol, D-79100 Freiburg, Germany

来源：

2005 3rd IEEE/EMBS Special Topic Conference on Microtechnology in Medicine and Biology | 2005年

关键词：

blood; hot embossing; injection molding; lab-on-a-chip; microchannel bend; microfluidic; polymer; separation; UV-LIGA;

D O I：

10.1109/MMB.2005.1548378

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Most clinical chemistry tests are performed on cell-free serum or plasma. Therefore micro assay devices for blood tests require integrated on-chip microfluidies for separation of plasma or serum from blood. These requirements of a convenient and inexpensive integrated microfluidies for blood separation are achieved by novel blood/plasma separation units based on microchannel bend structures. The microchannel bend technique combines two separation mechanisms, the centrifugal force and the so called "plasma-skimming" effect. A separation unit consists of a simple microchannel arrangement with branching channels. Prototype chips with separation units have been fabricated in COC polymers by micro injection molding or hot embossing. The red blood cell separation efficiency of different separation units has been tested with human whole blood or diluted blood samples. The results show different separation efficiencies up to 100 % for blood cells affected by channel geometry and fluid properties as well. As compared to present microfluidic devices like filters or filtration by diffusion, the results suggest the microchannel bend structures as an alternative and easily implementable, separation technique for lab-on-a-chip systems.

引用

页码：38 / 41

页数：4

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