RNA gene profile variation in peripheral blood mononuclear cells from rhesus macaques immunized with Hib conjugate vaccine, Hib capsular polysaccharide and TT carrier protein

被引：5

作者：

Tang, Jing ^{[1
,2
,3
]}

Zhang, Ying ^{[1
,2
]}

Zhang, Xiaolong ^{[1
,2
]}

Liao, Yun ^{[1
,2
]}

Wang, Yongrong ^{[1
,2
]}

Ouyang, Shengjie ^{[1
,2
]}

Che, Yanchun ^{[1
,2
]}

Xu, Miao ^{[3
]}

Pu, Jing ^{[1
,2
]}

Shen, Qi ^{[3
]}

He, Zhanlong ^{[1
,2
]}

Ye, Qiang ^{[3
]}

Li, Qihan ^{[1
,2
]}

机构：

[1] Chinese Acad Med Sci, Inst Med Biol, Yunnan Key Lab Vaccine Res & Dev Severe Infect Di, 935 Jiaoling Rd, Kunming 650118, Yunnan, Peoples R China

[2] Peking Union Med Coll, 935 Jiaoling Rd, Kunming 650118, Yunnan, Peoples R China

[3] Natl Inst Food & Drug Control, Beijing, Peoples R China

来源：

BMC IMMUNOLOGY | 2018年 / 19卷

关键词：

Haemophilus influenzae type b (Hib); Conjugate vaccine; Gene profile; INFLUENZAE TYPE-B; HAEMOPHILUS-INFLUENZAE; ANTIBODY-RESPONSES; SIGNAL-TRANSDUCTION; ADHESION MOLECULES; SERUM ANTIBODIES; INNATE IMMUNITY; UNITED-STATES; ONCOSTATIN-M; 13; PP13;

D O I：

10.1186/s12865-018-0240-5

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Background: The Haemophilus influenzae type b (Hib) conjugate vaccine has been widely used in children to prevent invasive Hib disease because of its strong immunogenicity and antibody response induction relative to the capsular polysaccharide (CPS) antigen. The data from vaccine studies suggest that the conjugate vaccine contains carrier proteins that enhance and/or regulate the antigen's immunogenicity, but the mechanism of this enhancement remains unclear. Methods: To explore the immunological role of the conjugate vaccine, we compared the immune responses and gene profiles of rhesus macaques after immunization with CPS, carrier protein tetanus toxoid (TT) or conjugate vaccine. Results: A distinct immune response was induced by the Hib conjugate vaccine but not by CPS or carrier protein TT. The genes that were dynamically regulated in conjunction with the macaque immune responses to the conjugate vaccine were investigated. Conclusions: We propose that these genes are involved in the induction of specific immunity that is characterized by the appearance and maintenance of antibodies against Hib.

引用

页数：13

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