Dendrobium officinale polysaccharides attenuate learning and memory disabilities via anti-oxidant and anti-inflammatory actions

被引：73

作者：

Liang, Jian ^{[1
,2
]}

Wu, Yanfang ^{[1
,2
]}

Yuan, Han ^{[1
,2
]}

Yang, Yiqi ^{[4
]}

Xiong, Qingping ^{[1
,2
]}

Liang, Chuyan ^{[5
]}

Li, Zhimeng ^{[7
]}

Li, Cantao ^{[3
]}

Zhang, Guifang ^{[1
,2
]}

Lai, Xiaoping ^{[1
,2
]}

Hu, Youdong ^{[6
]}

Hou, Shaozhen ^{[1
,2
,3
]}

机构：

[1] Guangzhou Univ Chinese Med, Guangdong Prov Key Lab New Drug Dev & Res Chinese, Guangzhou 510006, Guangdong, Peoples R China

[2] Guangzhou Univ Chinese Med, Math Engn Acad Chinese Med, Guangzhou 510006, Guangdong, Peoples R China

[3] Guangzhou Univ Chinese Med, Sch Pharmaceut Sci, Guangzhou 510006, Guangdong, Peoples R China

[4] Guangzhou Univ Chinese Med, Affiliated Hosp 2, Guangzhou 510006, Guangdong, Peoples R China

[5] Guangzhou Med Univ, Affiliated Hosp 1, Guangzhou 510080, Guangdong, Peoples R China

[6] Xuzhou Med Univ, Affiliated Huaian Hosp, Huaian 223002, Jiangsu, Peoples R China

[7] Fifth Peoples Hosp Tangshan, Tangshan 063004, Hebei, Peoples R China

来源：

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | 2019年 / 126卷 / 414-426期

关键词：

Dendrobium officinale; Polysaccharides; Learning and memory impairment; Oxidative stress; Neuro-inflammation; OXIDATIVE STRESS; COGNITIVE IMPAIRMENT; MOUSE MODEL; PROTECTIVE ROLES; WORKING-MEMORY; BRAIN-INJURY; MECHANISMS; RATS; OVARIECTOMY; INVOLVEMENT;

D O I：

10.1016/j.ijbiomac.2018.12.230

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The aim of this study was to explore the therapeutic effect and underling mechanism of Dendrobium officinale polysaccharides (DOPS) on two well-established animal models of learning and memory disabilities. Model of estrogen deficiency caused learning and memory disability can be induced by ovariectomy in mice, and mice were injected subcutaneously with D-galactose, which can also cause cognitive decline. H&E staining and Nissl staining were employed to confirm the protective effect of DOPS on hippocampal neuron. Morris water maze test, biochemical analysis, immunohistochemistry and immunofluorescence assay were used to study the effect and underlying mechanism of DOPS on two different learning and memory impairment models. Administration of DOPS significantly improved learning and memory disability in both models. Further studies showed that DOPS could attenuate oxidative stress and reduce neuro-inflammation via up-regulating expressions of Nrf2/HO-1 pathway and inhibiting activation of astrocytes and microglia in ovariectomy- and D-galactose-induced cognitive decline. These findings suggest that DOPS have an appreciable therapeutic effect on learning and memory disabilities and its mechanism may be related to activate Nrf2/HO-1 pathway to reduce oxidative stress and neuro-inflammation. (C) 2018 Elsevier B.V. All rights reserved.

引用

页码：414 / 426

页数：13

共 52 条

[1] Melatonin attenuates D-galactose-induced memory impairment, neuroinflammation and neurodegeneration via RAGE/NF-KB/JNK signaling pathway in aging mouse model [J].