Outcome of Chlamydia pneumoniae associated acute ischemic stroke in elderly patients: A case-control study

被引：9

作者：

Bandaru, V. C. S. Srinivasarao ^{[2
]}

Boddu, Demudu Babu ^{[1
]}

Mridula, K. Rukmini ^{[1
]}

Akhila, B. ^{[1
]}

Alladi, Suvarna ^{[1
]}

Laxmi, V. ^{[3
]}

Pathapati, Rammohan ^{[4
]}

Neeraja, M. ^{[3
]}

Kaul, Subhash ^{[1
]}

机构：

[1] Nizams Inst Med Sci, Dept Neurol, Hyderabad 500082, Andhra Pradesh, India

[2] Yashoda Hosp, Dept Clin Res, Hyderabad 500082, Andhra Pradesh, India

[3] Nizams Inst Med Sci, Dept Microbiol, Hyderabad 500082, Andhra Pradesh, India

[4] Narayana Med Coll & Hosp, Dept Clin Pharmacol, Nellore 524003, India

来源：

CLINICAL NEUROLOGY AND NEUROSURGERY | 2012年 / 114卷 / 02期

关键词：

Chlamydia pneumoniae antibodies; Microimmunofluorescence; Modified Rankin score; Outcome of stroke; NORTHERN MANHATTAN STROKE; CEREBROVASCULAR-DISEASE; CARDIOVASCULAR-DISEASE; STRAIN TWAR; INFECTION; RISK; SEROPOSITIVITY; ANTIBODIES; ATHEROSCLEROSIS; SEROPREVALENCE;

D O I：

10.1016/j.clineuro.2011.09.016

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background: Limited data exists about the role of Chlamydia pneumoniae elderly patients with acute ischemic stroke. Objective: To study the role of C. pneumoniae in elderly patients (age more than 65 years) with acute ischemic stroke and its impact on stroke out come. Methods: We recruited 100 elderly patients with acute ischemic stroke and 100 age and sex matched controls over a period of 2 years. IgG and IgA anti C pneumoniae antibodies were measured by microimmunofluorescence technique in patients and controls. Good outcome was defined as a Modified Rankin score (mRS) of <= 2. Results: We found C. pneumoniae antibodies in 35% stroke patients and in 18% control subjects (p = 0.01). Good out come at 90 days follow up was found in 20/35(57.1%) seropositive stroke patients compared to 37/65(56.9%) seronegative stroke patients (p = 0.9). Conclusions: C. pneumoniae antibody positivity was independently associated with ischemic stroke in elderly patients and its presence does not alter the stroke outcome. (C) 2011 Elsevier B.V. All rights reserved.

引用

页码：120 / 123

页数：4

共 38 条

[1] CLASSIFICATION OF SUBTYPE OF ACUTE ISCHEMIC STROKE - DEFINITIONS FOR USE IN A MULTICENTER CLINICAL-TRIAL [J].

ADAMS, HP ;

BENDIXEN, BH ;

KAPPELLE, LJ ;

BILLER, J ;

LOVE, BB ;

GORDON, DL ;

MARSH, EE ;

KASE, CS ;

WOLF, PA ;

BABIKIAN, VL ;

LICATAGEHR, EE ;

ALLEN, N ;

BRASS, LM ;

FAYAD, PB ;

PAVALKIS, FJ ;

WEINBERGER, JM ;

TUHRIM, S ;

RUDOLPH, SH ;

HOROWITZ, DR ;

BITTON, A ;

MOHR, JP ;

SACCO, RL ;

CLAVIJO, M ;

ROSENBAUM, DM ;

SPARR, SA ;

KATZ, P ;

KLONOWSKI, E ;

CULEBRAS, A ;

CAREY, G ;

MARTIR, NI ;

FICARRA, C ;

HOGAN, EL ;

CARTER, T ;

GURECKI, P ;

MUNTZ, BK ;

RAMIREZLASSEPAS, M ;

TULLOCH, JW ;

QUINONES, MR ;

MENDEZ, M ;

ZHANG, SM ;

ALA, T ;

JOHNSTON, KC ;

ANDERSON, DC ;

TARREL, RM ;

NANCE, MA ;

BUDLIE, SR ;

DIERICH, M ;

HELGASON, CM ;

HIER, DB ;

SHAPIRO, RA .

STROKE, 1993, 24 (01) :35-41

[2]

[Anonymous], 2002, NEUROL INDIA

[3] Chlamydia pneumoniae antibodies in various subtypes of ischemic stroke in Indian patients [J].

Bandaru, V. C. S. S. ;

Laxmi, V. ;

Neeraja, M. ;

Alladi, S. ;

Meena, A. K. ;

Borgohain, R. ;

Keerthi, A. S. ;

Kaul, S. .

JOURNAL OF THE NEUROLOGICAL SCIENCES, 2008, 272 (1-2) :115-122

[4] Seroprevalence of Chlamydia Pneumoniae Antibodies in Stroke in Young [J].

Bandaru, V. C. S. Srinivasarao ;

Boddu, D. Babu ;

Laxmi, V. ;

Neeraja, M. ;

Kaul, S. .

CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES, 2009, 36 (06) :725-730

[5] Antibodies to Chlamydia pneumoniae are Associated with Increased Intima Media Thickness in Asymptomatic Indian Individuals [J].

Bandaru, V. C. S. Srinivasarao ;

Kaul, Subhash ;

Laxmi, Vernu ;

Neeraja, M. ;

Mahesh, M. Uma ;

Alladi, Suvarna ;

Boddu, Demudu Babu .

JOURNAL OF STROKE & CEREBROVASCULAR DISEASES, 2009, 18 (03) :190-194

[6] Predictors of major neurological improvement after intravenous thrombolysis in acute ischemic stroke: A hospital-based study from south India [J].

Boddu, Demudu Babu ;

Bandaru, V. C. S. Srinivasarao ;

Reddy, Prasad G. ;

Madhusudan, M. ;

Rukmini, M. K. ;

Suryaprabha, T. ;

Jabeen, S. A. ;

Suvarna, A. ;

Jayalakshmi, Sita S. ;

Meena, A. K. ;

Borgohain, Rupam ;

Kaul, Subhash .

NEUROLOGY INDIA, 2010, 58 (03) :403-406

[7] Chlamydia pneumoniae and atherosclerosis:: Links to the disease process [J].

Byrne, GI ;

Kalayoglu, MV .

AMERICAN HEART JOURNAL, 1999, 138 (05) :S488-S490

[8] Chlamydia pneumoniae antibody titers are significantly associated with acute stroke and transient cerebral ischemia - The West Birmingham Stroke Project [J].

Cook, PJ ;

Honeybourne, D ;

Lip, GYH ;

Beevers, DG ;

Wise, R ;

Davies, P .

STROKE, 1998, 29 (02) :404-410

[9] Standardizing Chlamydia pneumoniae assays:: Recommendations from the Centers for Disease Control and Prevention (USA) and the Laboratory Centre for Disease Control (Canada) [J].

Dowell, SF ;

Peeling, RW ;

Boman, J ;

Carlone, GM ;

Fields, BS ;

Guarner, J ;

Hammerschlag, MR ;

Jackson, LA ;

Kuo, CC ;

Maass, M ;

Messmer, TO ;

Talkington, DF ;

Tondella, ML ;

Zaki, SR ;

Bandea, C ;

Black, C ;

O'Conner, S ;

Papp, J ;

Perilla, MJ ;

Schuchat, A ;

Stevens, V ;

Van Beneden, CA ;

Zell, ER ;

Cohen, C ;

Campbell, LA ;

Wwang, SP ;

Grayston, JT ;

Deal, CD ;

Gaydos, C ;

Schindler, L ;

Taylor, CE ;

Mahony, J ;

Fong, IW ;

Leinonen, M ;

Saikku, P ;

Maas, M ;

Ossewaarde, JM ;

Persson, K ;

Boman, J ;

Apfalter, P .

CLINICAL INFECTIOUS DISEASES, 2001, 33 (04) :492-502

[10] Chlamydia pneumoniae and the risk of first ischemic stroke -: The Northern Manhattan Stroke Study [J].

Elkind, MSV ;

Lin, IF ;

Grayston, JT ;

Sacco, RL .

STROKE, 2000, 31 (07) :1521-1525

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