Noscapine inhibits tumor growth in TMZ-resistant gliomas

被引：48
作者：
Jhaveri, Niyati [1 ]
Cho, Heeyeon [2 ]
Torres, Shering [1 ]
Wang, Weijun [2 ]
Schoenthal, Axel H. [3 ]
Petasis, Nicos A. [4 ]
Louie, Stan G. [5 ]
Hofman, Florence M. [1 ]
Chen, Thomas C. [1 ,2 ]
机构：
[1] Univ So Calif, Dept Pathol, Keck Sch Med, Los Angeles, CA 90033 USA
[2] Univ So Calif, Dept Neurosurg, Keck Sch Med, Los Angeles, CA 90033 USA
[3] Univ So Calif, Dept Mol Microbiol & Immunol, Keck Sch Med, Los Angeles, CA 90033 USA
[4] Univ So Calif, Coll Letters Arts & Sci, Dept Chem, Los Angeles, CA 90033 USA
[5] Univ So Calif, Sch Pharm, Dept Clin Pharm, Los Angeles, CA 90033 USA
来源：
CANCER LETTERS | 2011年 / 312卷 / 02期
关键词：
Glioma; Noscapine; Temozolomide-resistance; Invasion; Brain tumors; GLIOBLASTOMA-MULTIFORME; ADJUVANT TEMOZOLOMIDE; MICROTUBULE DYNAMICS; CANCER CELLS; APOPTOSIS; ANGIOGENESIS; PROGRESSION; CONCOMITANT; PATHWAY; AGENT;
D O I：
10.1016/j.canlet.2011.08.015
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Noscapine, a common oral antitussive agent, has been shown to have potent antitumor activity in a variety of cancers. Treatment of glioblastoma multiforme (GBM) with temozolomide (TMZ), its current standard of care, is problematic because the tumor generally recurs and is then resistant to this drug. We therefore investigated the effects of noscapine on human TMZ-resistant GBM tumors. We found that noscapine significantly decreased TMZ-resistant glioma cell growth and invasion. Using the intracranial xenograft model, we showed that noscapine increased survival of animals with TMZ-resistant gliomas. Thus noscapine can provide an alternative therapeutic approach for the treatment of TMZ-resistant gliomas. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：245 / 252
页数：8
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