Muscle-derived interleukin-6: possible biological effects

被引:414
作者
Pedersen, BK
Steensberg, A
Schjerling, P
机构
[1] Univ Copenhagen, Copenhagen Muscle Res Ctr, Copenhagen, Denmark
[2] Univ Copenhagen, Dept Infect Dis, Copenhagen, Denmark
来源
JOURNAL OF PHYSIOLOGY-LONDON | 2001年 / 536卷 / 02期
关键词
D O I
10.1111/j.1469-7793.2001.0329c.xd
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Interleukin-6 (IL-6) is produced locally in working skeletal muscle and can account for the increase in plasma IL-6 during exercise. The production of IL-6 during exercise is related to the intensity and duration of the exercise, and low muscle glycogen content stimulates the production. Muscle-derived IL-6 is released into the circulation during exercise in high amounts and is likely to work in a hormone-like fashion, exerting an effect on the liver and adipose tissue, thereby contributing to the maintenance of glucose homeostasis during exercise and mediating exercise-induced lipolysis. Muscle-derived IL-6 may also work to inhibit the effects of pro-inflammatory cytokines such as tumour necrosis factor alpha. The latter cytokine is produced by adipose tissue and inflammatory cells and appears to play a pathogenetic role in insulin resistance and atherogenesis.
引用
收藏
页码:329 / 337
页数:9
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