Multiple γc-dependent cytokines regulate T-cell development

被引：57

作者：

Malek, TR ^{[1
]}

Porter, BO

He, YW

机构：

[1] Univ Miami, Sch Med, Dept Microbiol & Immunol, Miami, FL 33136 USA

[2] Univ Washington, Sch Med, Dept Immunol, Seattle, WA 98195 USA

来源：

IMMUNOLOGY TODAY | 1999年 / 20卷 / 02期

关键词：

D O I：

10.1016/S0167-5699(98)01391-7

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Mutations in the common gamma chain (gamma c) of cytokine receptors account for human X-linked severe combined immunodeficiency disease, gamma c contributes to ligand binding and signaling as a component of five cytokine receptors: interleukin-2-receptor (IL-2R), IL-4R, IL-7R, IL-9R and IL-15R. Here, Thomas Malek and colleagues discuss the contribution of individual gamma c-dependent cytokines in both conventional and intraepithelial T-cell development.

引用

页码：71 / 76

页数：6

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