A role for the Agouti-Related Protein promoter in obesity and type 2 diabetes

被引：36

作者：

Mayfield, DK

Brown, AM

Page, GP

Garvey, WT

Shriver, MD

Argyropoulos, G

机构：

[1] Med Univ S Carolina, Dept Med, Strom Thurmond Biomed Res Ctr, Charleston, SC 29403 USA

[2] Med Univ S Carolina, Dept Biometry, Strom Thurmond Biomed Res Ctr, Charleston, SC 29403 USA

[3] Penn State Univ, Dept Anthropol, University Pk, PA 16802 USA

[4] Pennington Biomed Res Ctr, Baton Rouge, LA 70808 USA

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2001年 / 287卷 / 02期

关键词：

D O I：

10.1006/bbrc.2001.5600

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The murine Agouti-Related Protein (mAGRP) is upregulated in obese and diabetic mice and can stimulate hyperphagia when overexpressed in transgenic models. Here we report upstream nucleotide sequences of the human hAGRP gene with putative recognition sites for transcription factors including a site for the STAT transactivators. A polymorphism (-38C -->T) was identified in the promoter region and the CIC genotype had significantly higher promoter activity and affinity for transcription factors as tested in periphery- and hypothalamus-derived cell lines. The polymorphic site could affect the expression levels of hAGRP and the high expressing CIC genotype was significantly associated with high BMI and type 2 diabetes in Africans. (C) 2001 Academic Press.

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收藏

页码：568 / 573

页数：6

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