ZHX1 Promotes the Proliferation, Migration and Invasion of Cholangiocarcinoma Cells

被引：14
|
作者：
Kwon, Ryuk-Jun [1 ,2 ]
Han, Myoung-Eun [1 ,2 ]
Kim, Ji-young [1 ,2 ]
Liu, Liangwen [1 ,2 ]
Kim, Yun-Hak [1 ,2 ]
Jung, Jin-Sup [3 ]
Oh, Sae-Ock [1 ,2 ]
机构：
[1] Pusan Natl Univ, Sch Med, Dept Anat, Busandaehak Ro 49, Yangsan 50612, South Korea
[2] Pusan Natl Univ, Gene & Therapy Res Ctr Vessel Associated Dis, Busandaehak Ro 49, Yangsan 50612, South Korea
[3] Pusan Natl Univ, Dept Physiol, Sch Med, Busandaehak Ro 49, Yangsan 50612, South Korea
来源：
PLOS ONE | 2016年 / 11卷 / 11期
基金：
新加坡国家研究基金会;
关键词：
ZINC-FINGERS; TRANSCRIPTION FACTOR; GENE-EXPRESSION; PROSTATE-CANCER; TARGETS; GROWTH; EGR1;
D O I：
10.1371/journal.pone.0165516
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Zinc-fingers and homeoboxes 1 (ZHX1) is a transcription repressor that has been associated with the progressions of hepatocellular carcinoma, gastric cancer, and breast cancer. However, the functional roles of ZHX1 in cholangiocarcinoma (CCA) have not been determined. We investigated the expression and roles of ZHX1 during the proliferation, migration, and invasion of CCA cells. In silico analysis and immunohistochemical studies showed amplification and overexpression of ZHX1 in CCA tissues. Furthermore, ZHX1 knockdown using specific siRNAs decreased CCA cell proliferation, migration, and invasion, whereas ZHX1 overexpression promoted all three characteristics. In addition, results suggested EGR1 might partially mediate the effect of ZHX1 on the proliferation of CCA cells. Taken together, these results show ZHX1 promotes CCA cell proliferation, migration, and invasion, and present ZHX1 as a potential target for the treatment of CCA.
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页数：15
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