Where's the Beef? Understanding Allergic Responses to Red Meat in Alpha-Gal Syndrome

被引：20

作者：

Carson, Audrey S.

Gardner, Aliyah

Iweala, Onyinye I.

机构：

[1] Univ N Carolina, Sch Med, Dept Med, Thurston Arthrit Res Ctr,Div Rheumatol Allergy &, Chapel Hill, NC 27599 USA

[2] Univ N Carolina, Dept Pediat, Univ North Carolina Food Allergy Initiat, Div Allergy & Immunol,Sch Med, Chapel Hill, NC 27599 USA

来源：

JOURNAL OF IMMUNOLOGY | 2022年 / 208卷 / 02期

基金：

美国国家卫生研究院;

关键词：

T(H)2 CELL-DIFFERENTIATION; LONE STAR TICK; KILLER T-CELLS; IGE ANTIBODIES; MAMMALIAN MEAT; B-CELLS; INDUCED ANAPHYLAXIS; ANTI-GAL; GALACTOSE-ALPHA-1,3-GALACTOSE; ASSOCIATION;

D O I：

10.4049/jimmunol.2100712

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Alpha-gal syndrome (AGS) describes a collection of symptoms associated with IgE-mediated hypersensitivity responses to the glycan galactose-alpha-1,3 galactose (alpha-gal). Individuals with AGS develop delayed hypersensitivity reactions, with symptoms occurring >2 h after consuming mammalian ("red") meat and other mammal-derived food products. The mechanisms of pathogenesis driving this paradigm breaking food allergy are not fully understood. We review the role of tick bites in the development of alpha-gal -specific IgE and highlight innate and adaptive immune cells possibly involved in alpha-gal sensitization. We discuss the impact of alpha-gal glycosylation on digestion and metabolism of alpha-gal glycolipids and glycoproteins, and the implications for basophil and mast cell activation and mediator release that generate allergic symptoms in AGS.

引用

页码：267 / 277

页数：12

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