PyBidine-NiCl2-Catalyzed Asymmetric Addition of Alcohols and Peroxides to Isatin-Derived Ketimines

被引：77
作者：
Arai, Takayoshi [1 ]
Tsuchiya, Kento [1 ]
Matsumura, Eri [1 ]
机构：
[1] Chiba Univ, Grad Sch Sci, Dept Chem, Inage Ku, Chiba 2638522, Japan
来源：
ORGANIC LETTERS | 2015年 / 17卷 / 10期
关键词：
HIGHLY ENANTIOSELECTIVE ADDITION; NITRO-MANNICH REACTION; OXIDATIVE ENTRY; HYDROPEROXIDATION; COMPLEXES; ALKALOIDS; CATALYSTS; AMIDES; IMINES; ENALS;
D O I：
10.1021/acs.orglett.5b00928
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An (S,S)-diphenyldiamine-derived bis(imidazolidine)pyridine (PyBidine)-NiCl2 complex catalyzed the asymmetric addition of methanol and peroxides to isatin-derived N-Boc-imines to form chiral quaternary N,O-acetals at the C3 position of the resulting oxiindoles in up to 99% yield with 94% ee.
引用
收藏
页码：2416 / 2419
页数：4
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