Targeting STAT3 in cancer and autoimmune diseases

被引：88

作者：

Gharibi, Tohid ^{[1
,2
,3
,4
]}

Babaloo, Zohreh ^{[1
,2
]}

Hosseini, Arezoo ^{[1
,2
,3
,4
]}

Abdollahpour-alitappeh, Meghdad ^{[5
]}

Hashemi, Vida ^{[1
,6
]}

Marofi, Faroogh ^{[2
]}

Nejati, Kazem ^{[7
]}

Baradaran, Behzad ^{[1
,2
]}

机构：

[1] Tabriz Univ Med Sci, Immunol Res Ctr, Tabriz, Iran

[2] Tabriz Univ Med Sci, Sch Med, Dept Immunol, Tabriz, Iran

[3] Tabriz Univ Med Sci, Student Res Comm, Tabriz, Iran

[4] Tabriz Univ Med Sci, Aging Res Inst, Tabriz, Iran

[5] Larestan Univ Med Sci, Sch Nursing, Dept Nursing, Larestan, Iran

[6] Maragheh Univ Med Sci, Dept Basic Sci, Fac Med, Maragheh, Iran

[7] Ardabil Univ Med Sci, Pharmaceut Sci Res Ctr, Ardebil, Iran

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 2020年 / 878卷

关键词：

STAT3; Cancer; Autoimmune diseases; Small molecule inhibitors; EPIDERMAL-GROWTH-FACTOR; TRANSCRIPTION FACTOR STAT3; DNA-BINDING DOMAIN; SMALL-MOLECULE INHIBITOR; EPITHELIAL-MESENCHYMAL TRANSITION; JANUS KINASE/SIGNAL TRANSDUCER; ACTIVE RHEUMATOID-ARTHRITIS; ACUTE-PHASE RESPONSE; APOPTOSIS IN-VITRO; T-CELL LYMPHOMA;

D O I：

10.1016/j.ejphar.2020.173107

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Signal transducer and activator of transcription 3 (STAT3) is a transcription factor that is activated downstream of a broad range of receptors particularly interleukin-6 (IL-6) family. STAT3 is the key regulator of cell proliferation, survival and apoptosis and is constitutively activated in most human cancers, indicating that it can be an important potential therapeutic target for cancer treatment. STAT3 also has important roles in lymphocyte biology, regulation of immune responses and autoimmunity. Considering the vital role of STAT3 in tumor progression and autoimmunity, scientists have focused to develop small molecules that suppress STAT3 function. In this review, we firstly discussed the predominant role of STAT3 in cancer and autoimmune diseases. Subsequently, we discussed the efficacy and therapeutic potential of different STAT3 inhibitors in cancer and autoimmune diseases in preclinical studies and clinical trials offering an insight into novel approaches for development of new STAT3 inhibitors.

引用

页数：19

共 358 条

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