Chichibabin pyridinium synthesis

被引：7

作者：

Imura, Akiho ^{[1
]}

Tanaka, Nao ^{[1
]}

Usuki, Toyonabu ^{[1
]}

机构：

[1] Sophia Univ, Fac Sci & Technol, Dept Mat & Life Sci, Chiyoda Ku, 7-1 Kioicho, Tokyo 1028554, Japan

来源：

TETRAHEDRON LETTERS | 2019年 / 60卷 / 06期

关键词：

Chichibabin pyridinium synthesis; Tetrasubstituted pyridinium; Pr(OTf)(3); Aldol condensation; CROSS-LINKAGES; ALDEHYDES; ISODESMOSINE; MECHANISM;

D O I：

10.1016/j.tetlet.2019.01.011

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Chichibabin pyridine synthesis involves the reaction of three aldehydes and ammonia to form 2,3,5-trisubstituted pyridines. This study examined the synthesis of tetrasubstituted pyridinium from aldehydes and an amine hydrochloride in the presence/absence of Pr(OTf)(3). Important insights into the reaction mechanisms of Chichibabin pyridinium synthesis were proposed through the investigation of reaction intermediates along with quantitative GC-MS analysis. (C) 2019 Elsevier Ltd. All rights reserved.

引用

页码：489 / 492

页数：4

共 12 条

[1] Mechanism of formation of elastin crosslinks [J].