Gut Microbiota as the Link between Elevated BCAA Serum Levels and Insulin Resistance

被引:94
作者
Gojda, Jan [1 ,2 ]
Cahova, Monika [3 ]
机构
[1] Charles Univ Prague, Kralovske Vinohrady Univ Hosp, Dept Internal Med, Prague 10000, Czech Republic
[2] Charles Univ Prague, Fac Med 3, Prague 10000, Czech Republic
[3] Inst Clin & Expt Med, Prague 14021, Czech Republic
关键词
branched-chain amino acids; insulin resistance; type; 2; diabetes; gut microbiome; gut metabolome; CHAIN AMINO-ACIDS; NITROGEN-METABOLISM ROLE; WEIGHT-LOSS; LEUCINE; HOST; AVAILABILITY; HOMEOSTASIS; LYSINE; N-15; CONSEQUENCES;
D O I
10.3390/biom11101414
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The microbiota-harboring human gut is an exquisitely active ecosystem that has evolved in a constant symbiosis with the human host. It produces numerous compounds depending on its metabolic capacity and substrates availability. Diet is the major source of the substrates that are metabolized to end-products, further serving as signal molecules in the microbiota-host cross-talk. Among these signal molecules, branched-chain amino acids (BCAAs) has gained significant scientific attention. BCAAs are abundant in animal-based dietary sources; they are both produced and degraded by gut microbiota and the host circulating levels are associated with the risk of type 2 diabetes. This review aims to summarize the current knowledge on the complex relationship between gut microbiota and its functional capacity to handle BCAAs as well as the host BCAA metabolism in insulin resistance development. Targeting gut microbiota BCAA metabolism with a dietary modulation could represent a promising approach in the prevention and treatment of insulin resistance related states, such as obesity and diabetes.
引用
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页数:16
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