Luminescent, mesoporous, and bioactive europium-doped calcium silicate (MCS: Eu3+) as a drug carrier

被引：29
作者：
Fan, Yong [1 ,2 ]
Huang, Shanshan [1 ]
Jiang, Jinhua [2 ]
Li, Guogang [1 ]
Yang, Piaoping [1 ]
Lian, Hongzhou [1 ]
Cheng, Ziyong [1 ]
Lin, Jun [1 ]
机构：
[1] Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Rare Earth Resource Utilizat, Changchun 130022, Peoples R China
[2] Jilin Univ, Coll Chem, State Key Lab Inorgan Synth & Preparat Chem, Changchun 130022, Jilin, Peoples R China
来源：
JOURNAL OF COLLOID AND INTERFACE SCIENCE | 2011年 / 357卷 / 02期
基金：
中国国家自然科学基金;
关键词：
Drug delivery; Luminescence; Calcium silicate; Mesoporous; Bioactive; IN-VITRO BIOACTIVITY; SIMULATED BODY-FLUID; SOL-GEL GLASSES; DELIVERY-SYSTEM; CASIO3; POWDERS; RARE-EARTH; PHOSPHATE; RELEASE; HYDROXYAPATITE; CERAMICS;
D O I：
10.1016/j.jcis.2011.01.109
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
Luminescent, mesoporous, and bioactive europium-doped calcium silicate (MCS: Eu) was successfully synthesized. The obtained MCS: Eu3+ was performed as a drug delivery carrier to investigate the drug storage/release properties using ibuprofen (IBU) as the model drug. The structural, morphological, textural, and optical properties were well characterized by X-ray diffraction (XRD), transmission electron microscopy (TEM), N-2 adsorption/desorption, and photoluminescence (PL) spectra, respectively. The results reveal that the MCS: Eu exhibits the typical ordered characteristics of the mesostructure. This composite shows a sustained release profile with IBU as the model drug. The IBU-loaded samples still present red luminescence of Eu3+ (D-5(0)-F-7(1.2)) under UV irradiation. The emission intensities of Eu3+ in the drug carrier system vary with the amount of released IBU, making the drug release easily tracked and monitored. The system demonstrates a great potential for drug delivery and disease therapy. (C) 2011 Elsevier Inc. All rights reserved.
引用
收藏
页码：280 / 285
页数：6
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