We performed ultrasound-assisted extraction coupled with natural deep eutectic solvents (NADES) to achieve the green and efficient preparation of flavonoid extract from Ampelopsis grossedentata leaves. We then evaluated its antioxidant and antiproliferative activities. A NADES consisting of choline chloride and glucose at a molar ratio of 4:1 with 20% water was determined to be the most suitable solvent. The optimal extraction conditions were: a liquid-to-solid ratio of 30 mL/g, an ultrasonication power of 490 W, and an ultrasonication time of 6.5 min. The actual flavonoid yield was 83.93%, which was close to the predicted yield. Further, 86.75% of the flavonoids were recovered by adding the same volume of phosphate buffer saline (100 mM, pH of 7.0) to the extract solution. Although the chemical antioxidant activities of the flavonoid extract were slightly inferior to those of dihydromyricetin, the flavonoid extract could still effectively inhibit the proliferation of human breast MDA-MB-231 cells by inducing cell apoptosis, retarding the cell cycle, changing the mitochondrial membrane potential and scavenging intracellular reactive oxygen species (ROS). The obtained results can provide a reference in the development of plant-derived functional foods.
机构:
Univ La Serena, Food Engn Dept, Av Raul,Bitran Nachary 1305, La Serena, Chile
Adv Studies Ctr Arid Zones, CEAZA, Av Raul Bitran Nachary 1305, La Serena, ChileUniv La Serena, Food Engn Dept, Av Raul,Bitran Nachary 1305, La Serena, Chile
Briones-Labarca, Vilbett
;
Giovagnoli-Vicuna, Claudia
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Univ La Serena, Food Engn Dept, Av Raul,Bitran Nachary 1305, La Serena, ChileUniv La Serena, Food Engn Dept, Av Raul,Bitran Nachary 1305, La Serena, Chile
Giovagnoli-Vicuna, Claudia
;
Canas-Sarazua, Raul
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Univ La Serena, Food Engn Dept, Av Raul,Bitran Nachary 1305, La Serena, ChileUniv La Serena, Food Engn Dept, Av Raul,Bitran Nachary 1305, La Serena, Chile
机构:
Univ Zagreb, Fac Food Technol & Biotechnol, Pierottijeva 6, Zagreb 10000, CroatiaUniv Zagreb, Fac Food Technol & Biotechnol, Pierottijeva 6, Zagreb 10000, Croatia
Bubalo, Marina Cvjetko
;
Curko, Natka
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Univ Zagreb, Fac Food Technol & Biotechnol, Pierottijeva 6, Zagreb 10000, CroatiaUniv Zagreb, Fac Food Technol & Biotechnol, Pierottijeva 6, Zagreb 10000, Croatia
Curko, Natka
;
Tomasevic, Marina
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Univ Zagreb, Fac Food Technol & Biotechnol, Pierottijeva 6, Zagreb 10000, CroatiaUniv Zagreb, Fac Food Technol & Biotechnol, Pierottijeva 6, Zagreb 10000, Croatia
Tomasevic, Marina
;
Ganic, Karin Kovacevic
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Univ Zagreb, Fac Food Technol & Biotechnol, Pierottijeva 6, Zagreb 10000, CroatiaUniv Zagreb, Fac Food Technol & Biotechnol, Pierottijeva 6, Zagreb 10000, Croatia
机构:
Virginia Tech, Dept Food Sci & Technol, 402A HABB1,1230 Washington St SW, Blacksburg, VA 24061 USAVirginia Tech, Dept Food Sci & Technol, 402A HABB1,1230 Washington St SW, Blacksburg, VA 24061 USA
Carneiro, Renata C. V.
;
Ye, Liyun
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Virginia Tech, Dept Food Sci & Technol, 402A HABB1,1230 Washington St SW, Blacksburg, VA 24061 USAVirginia Tech, Dept Food Sci & Technol, 402A HABB1,1230 Washington St SW, Blacksburg, VA 24061 USA
Ye, Liyun
;
Baek, Naerin
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Virginia Tech, Dept Food Sci & Technol, 402A HABB1,1230 Washington St SW, Blacksburg, VA 24061 USAVirginia Tech, Dept Food Sci & Technol, 402A HABB1,1230 Washington St SW, Blacksburg, VA 24061 USA
Baek, Naerin
;
Teixeira, Gustavo H. A.
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机构:
Univ Estadual Paulista, Dept Ciencias Prod Agr, Fac Ciencias Agr & Vet, Jaboticabal, SP, BrazilVirginia Tech, Dept Food Sci & Technol, 402A HABB1,1230 Washington St SW, Blacksburg, VA 24061 USA
Teixeira, Gustavo H. A.
;
O'Keefe, Sean F.
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Virginia Tech, Dept Food Sci & Technol, 402A HABB1,1230 Washington St SW, Blacksburg, VA 24061 USAVirginia Tech, Dept Food Sci & Technol, 402A HABB1,1230 Washington St SW, Blacksburg, VA 24061 USA
机构:
Univ La Serena, Food Engn Dept, Av Raul,Bitran Nachary 1305, La Serena, Chile
Adv Studies Ctr Arid Zones, CEAZA, Av Raul Bitran Nachary 1305, La Serena, ChileUniv La Serena, Food Engn Dept, Av Raul,Bitran Nachary 1305, La Serena, Chile
Briones-Labarca, Vilbett
;
Giovagnoli-Vicuna, Claudia
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h-index: 0
机构:
Univ La Serena, Food Engn Dept, Av Raul,Bitran Nachary 1305, La Serena, ChileUniv La Serena, Food Engn Dept, Av Raul,Bitran Nachary 1305, La Serena, Chile
Giovagnoli-Vicuna, Claudia
;
Canas-Sarazua, Raul
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Univ La Serena, Food Engn Dept, Av Raul,Bitran Nachary 1305, La Serena, ChileUniv La Serena, Food Engn Dept, Av Raul,Bitran Nachary 1305, La Serena, Chile
机构:
Univ Zagreb, Fac Food Technol & Biotechnol, Pierottijeva 6, Zagreb 10000, CroatiaUniv Zagreb, Fac Food Technol & Biotechnol, Pierottijeva 6, Zagreb 10000, Croatia
Bubalo, Marina Cvjetko
;
Curko, Natka
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h-index: 0
机构:
Univ Zagreb, Fac Food Technol & Biotechnol, Pierottijeva 6, Zagreb 10000, CroatiaUniv Zagreb, Fac Food Technol & Biotechnol, Pierottijeva 6, Zagreb 10000, Croatia
Curko, Natka
;
Tomasevic, Marina
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h-index: 0
机构:
Univ Zagreb, Fac Food Technol & Biotechnol, Pierottijeva 6, Zagreb 10000, CroatiaUniv Zagreb, Fac Food Technol & Biotechnol, Pierottijeva 6, Zagreb 10000, Croatia
Tomasevic, Marina
;
Ganic, Karin Kovacevic
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h-index: 0
机构:
Univ Zagreb, Fac Food Technol & Biotechnol, Pierottijeva 6, Zagreb 10000, CroatiaUniv Zagreb, Fac Food Technol & Biotechnol, Pierottijeva 6, Zagreb 10000, Croatia
机构:
Virginia Tech, Dept Food Sci & Technol, 402A HABB1,1230 Washington St SW, Blacksburg, VA 24061 USAVirginia Tech, Dept Food Sci & Technol, 402A HABB1,1230 Washington St SW, Blacksburg, VA 24061 USA
Carneiro, Renata C. V.
;
Ye, Liyun
论文数: 0引用数: 0
h-index: 0
机构:
Virginia Tech, Dept Food Sci & Technol, 402A HABB1,1230 Washington St SW, Blacksburg, VA 24061 USAVirginia Tech, Dept Food Sci & Technol, 402A HABB1,1230 Washington St SW, Blacksburg, VA 24061 USA
Ye, Liyun
;
Baek, Naerin
论文数: 0引用数: 0
h-index: 0
机构:
Virginia Tech, Dept Food Sci & Technol, 402A HABB1,1230 Washington St SW, Blacksburg, VA 24061 USAVirginia Tech, Dept Food Sci & Technol, 402A HABB1,1230 Washington St SW, Blacksburg, VA 24061 USA
Baek, Naerin
;
Teixeira, Gustavo H. A.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Estadual Paulista, Dept Ciencias Prod Agr, Fac Ciencias Agr & Vet, Jaboticabal, SP, BrazilVirginia Tech, Dept Food Sci & Technol, 402A HABB1,1230 Washington St SW, Blacksburg, VA 24061 USA
Teixeira, Gustavo H. A.
;
O'Keefe, Sean F.
论文数: 0引用数: 0
h-index: 0
机构:
Virginia Tech, Dept Food Sci & Technol, 402A HABB1,1230 Washington St SW, Blacksburg, VA 24061 USAVirginia Tech, Dept Food Sci & Technol, 402A HABB1,1230 Washington St SW, Blacksburg, VA 24061 USA