Systematic assessment of training-induced changes in corticospinal output to hand using frameless stereotaxic transcranial magnetic stimulation

被引：82
作者：
Kleim, Jeffrey A. [1 ,2 ]
Kleim, Erin D. [1 ,2 ]
Cramer, Steven C. [3 ,4 ]
机构：
[1] Malcom Randall VA Hosp, Brain Rehabil Res Ctr, Gainesville, FL 32608 USA
[2] Univ Florida, McKnight Brain Inst, Dept Neurosci, Gainesville, FL 32610 USA
[3] Univ Calif Irvine, Dept Neurol, UCI Med Ctr, Orange, CA 92868 USA
[4] Univ Calif Irvine, Dept Anat & Neurobiol, UCI Med Ctr, Orange, CA 92868 USA
来源：
NATURE PROTOCOLS | 2007年 / 2卷 / 07期
关键词：
D O I：
10.1038/nprot.2007.206
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Measuring changes in the characteristics of corticospinal output has become a critical part of assessing the impact of motor experience on cortical organization in both the intact and injured human brain. In this protocol we describe a method for systematically assessing training-induced changes in corticospinal output that integrates volumetric anatomical MRI with transcranial magnetic stimulation (TMS). A TMS coil is sited to a target grid superimposed onto a 3D MRI of cortex using a stereotaxic neuronavigation system. Subjects are then required to exercise the first dorsal interosseus (FDI) muscle on two different tasks for a total of 30 min. The protocol allows for reliably and repeatedly detecting changes in corticospinal output to FDI muscle in response to brief periods of motor training.
引用
收藏
页码：1675 / 1684
页数：10
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