Oxidized LDLs trigger endoplasmic reticulum stress and autophagy Prevention by HDLs

被引：52

作者：

Muller, Carole ^{[1
]}

Salvayre, Robert ^{[1
,2
]}

Negre-Salvayre, Anne ^{[1
]}

Vindis, Cecile ^{[1
]}

机构：

[1] INSERM, U 1048, I2MC, Toulouse, France

[2] Univ Toulouse 3, Fac Med, F-31062 Toulouse, France

来源：

AUTOPHAGY | 2011年 / 7卷 / 05期

关键词：

oxidized LDL; HDL; apoptosis; endoplasmic reticulum stress; autophagy;

D O I：

10.4161/auto.7.5.15003

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Oxidized LDLs (oxLDLs) induce various cellular dysfunctions potentially implicated in the pathogenesis of atherosclerosis. For instance, toxic concentrations of oxLDLs trigger ER stress, autophagy and apoptosis. High-density lipoproteins (HDLs) counteract several adverse biological effects triggered by oxLDLs. Our recent study reveals that HDLs inhibit the activation of ER stress and of autophagy induced by oxLDLs.

引用

页码：541 / 543

页数：3