The interaction of sarin and soman with plasma proteins: the identification of a novel phosphonylation site

被引：74
作者：
Black, RM [1 ]
Harrison, JM [1 ]
Read, RW [1 ]
机构：
[1] DERA, CBD Porton Down, Salisbury SP4 0JQ, Wilts, England
来源：
ARCHIVES OF TOXICOLOGY | 1999年 / 73卷 / 02期
关键词：
sarin; soman; protein binding; tyrosine residue; biomarker;
D O I：
10.1007/s002040050596
中图分类号：
R99 [毒物学（毒理学）];
学科分类号：
100405 ;
摘要：
Incubation of both sarin and soman with human plasma has shown that binding occurs to a tyrosine residue. Similar binding occurs when sarin and soman are incubated with human serum albumin. This binding may provide an important biological marker, which retains full structural information concerning the identity of the agent, in cases of allegations of chemical warfare use.
引用
收藏
页码：123 / 126
页数：4
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