Immunotherapy earns its spot in the ranks of cancer therapy

被引:109
作者
Pardoll, Drew [1 ]
Drake, Charles [1 ]
机构
[1] Johns Hopkins Univ, Sch Med, Sidney Kimmel Comprehens Canc Ctr, Baltimore, MD 21231 USA
关键词
LYMPHOCYTE-ASSOCIATED ANTIGEN-4; T-CELL-ACTIVATION; CHRONIC VIRAL-INFECTION; B7; FAMILY; METASTATIC MELANOMA; ANTITUMOR IMMUNITY; CARCINOMA PATIENTS; ANTIBODY BLOCKADE; CTLA-4; RECEPTORS; DEFICIENT MICE;
D O I
10.1084/jem.20112275
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Since it became clear that all cancer cells express tumor-specific and tumor-selective antigens generated by genetic alterations and epigenetic dysregulation, the immunology community has embraced the possibility of designing therapies to induce targeted antitumor immune responses. The potential therapeutic specificity and efficacy of such treatments are obvious to anyone who studies the exquisite specificity and cytocidal potency of immune responses. However, the value assigned to a therapeutic modality by the oncology community at large does not depend on scientific principle; all that matters is how patients respond. The bar for the ultimate acceptance of a therapy requires more than anecdotal clinical responses; rather, the major modalities of cancer therapeutics, including surgery, chemotherapy, radiation therapy, and, more recently, drugs targeting oncogenes, have earned their place only after producing dramatic frequent clinical responses or demonstrating statistically significant survival benefits in large randomized phase 3 clinical trials, leading to FDA approval. Although tumor-targeted antibodies have certainly cleared this bar, immunotherapies aimed at harnessing antitumor cellular responses have not-until now.
引用
收藏
页码:201 / 209
页数:9
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