Exudation: an expanding technique for continuous production and release of secondary metabolites from plant cell suspension and hairy root cultures

被引:104
作者
Cai, Zhenzhen [1 ]
Kastell, Anja [1 ]
Knorr, Dietrich [1 ]
Smetanska, Iryna [1 ,2 ]
机构
[1] Berlin Univ Technol, Inst Food Biotechnol & Food Chem, D-14195 Berlin, Germany
[2] Univ Appl Sci Weihenstephan Triesdorf, Dept Plant Food Proc, D-91746 Weidenbach, Germany
关键词
Exudation; Cell culture; Hairy root; Secondary metabolite; Medium; Elicitor; Membrane permeabilization; Product recovery; PULSED ELECTRIC-FIELDS; LOW-ENERGY ULTRASOUND; IN-SITU ADSORPTION; HIGH HYDROSTATIC-PRESSURE; STORED TROPANE ALKALOIDS; VITIS-VINIFERA L; ARTEMISIA-ANNUA L; METHYL-JASMONATE; ENHANCED PRODUCTION; CATHARANTHUS-ROSEUS;
D O I
10.1007/s00299-011-1165-0
中图分类号
Q94 [植物学];
学科分类号
071001 ;
摘要
This review addresses methods of obtaining secondary metabolites from plant cell suspension and hairy root cultures and their exudates, particularly the physiological mechanisms of secondary metabolites release and trafficking. The efficiency for product recovery of metabolites can be increased by various methods, based on the principle of continuous product release into the cultivation medium. The most common methods for metabolite recovery are elicitation, influencing membrane permeability, and in situ product removal. The biosynthetic pathways can be influenced by cultivation conditions, transformation, or application of elicitors. The membrane permeability can be altered through the application of chemical or physical treatments. Product removal can be greatly increased through a two-phase system and the introduction of absorbents into the cultivation medium. In this review, we describe some improved approaches that have proven useful in these efforts.
引用
收藏
页码:461 / 477
页数:17
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