Hypercholesterolemia and LDL apheresis

被引：11

作者：

Morelli, F ^{[1
]}

Carlier, R ^{[1
]}

Giannini, G ^{[1
]}

De Luigi, MC ^{[1
]}

Dejana, A ^{[1
]}

Ruzzenenti, MR ^{[1
]}

Valbonesi, M ^{[1
]}

机构：

[1] San Martino Univ Hosp, Immunohematol Dept, Serv Immunohematol, I-16132 Genoa, Italy

来源：

INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS | 2005年 / 28卷 / 10期

关键词：

familial hypercholesterolemia; coronary angiographic trials; immunoadsorption; dextran sulphate absorption; lipidfiltration; HELP; DALI;

D O I：

10.1177/039139880502801010

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Several trials have assessed the link between low-density lipoprotein cholesterol (LDL) and the development of coronary heart disease (CHD). LDL apheresis provides an effective role in treating patients with familial hypercholesterolemia (FH) and in preventing the progression of coronary artery disease (CAD). Five different techniques of LDL apheresis are in current use: immunoadsorption (IMA), dextran sulphate-cellulose adsorption (DSA), heparin extracorporeal LDL precipitation system (HELP), double filtration plasmapheresis (DFPP) or lipidffltration and direct adsorption of lipoprotein using hemoperfusion (DALI). All methods are efficient, but their cost restricts LDL apheresis to the treatment of FH. Indications could include other diseases, but controlled trials are still lacking.

引用

页码：1025 / 1031

页数：7

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