Molecular characterisation of methicillin resistant Staphylococcus aureus strains ST398 in patients with skin infections and their relatives

被引：6
作者：
Aspiroz, Carmen [1 ]
Lozano, Carmen [2 ]
Gilaberte, Yolanda [3 ]
Zarazaga, Myriam [2 ]
Jose Aldea, M. [1 ]
Torres, Carmen [2 ]
机构：
[1] Hosp Royo Villanova, Unidad Microbiol, Zaragoza, Spain
[2] Univ La Rioja, Area Bioquim & Biol Mol, Logrono, Spain
[3] Hosp San Jorge, Serv Dermatol, Huesca, Spain
来源：
ENFERMEDADES INFECCIOSAS Y MICROBIOLOGIA CLINICA | 2012年 / 30卷 / 01期
关键词：
Staphylococcus aureus; Methicillin resistant Staphylococcus aureus; Sequence Type 398; Tetracycline; Pigs; Skin and soft tissue infections; ANIMALS;
D O I：
10.1016/j.eimc.2011.07.013
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
Introduction: Livestock-associated methicillin-resistant Staphylococcus aureus (LA-MRSA) of sequence type ST398 is a genetic lineage also described in human infections. Methods: Cutaneous infections related with MRSA ST398 are described in 3 patients, two of them pig farmers. The MRSA nasal carriage by patients and their relatives was also studied. MRSA ST398 strains were typed (SCCmec, spa, agr and MLST) and the antimicrobial resistance pattern and virulence genes were determined. Results: Twenty MRSA ST398 isolates were recovered in lesions of three patients, and in nasal samples of two patients and five relatives. Isolates were typed: spa-type t011 or t108; agr-type I and SCCmec IVa or V. MRSA strains were tetracycline-resistant and 15 of them showed a phenotype and genotype of multi-resistance, but they were free of tested virulence genes. Conclusions: LA-MRSA ST398 is an emergent problem in our country, mainly associated with skin and soft tissue infections in people with professional relationships with pig farms. Tetracycline resistance is an important marker for MRSA ST398 detection. (C) 2011 Elsevier Espana, S.L. All rights reserved.
引用
收藏
页码：18 / 21
页数：4
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