Analysis of Polymorphic Variants of PDE4D Gene in Patients with Acute Stroke from Moldavian Population

被引：0
作者：
Bondarenko, E. A. [1 ]
Mocan, E. I. [2 ,3 ]
Barbacar, N. I. [2 ]
Tupitsyna, T. V. [1 ]
Slominskii, P. A. [1 ]
Shetova, I. M. [4 ]
Shamalov, N. A. [4 ]
Botsina, A. Yu. [4 ]
Skvortsova, V. I. [4 ]
Limborska, S. A. [1 ]
机构：
[1] Russian Acad Sci, Inst Mol Genet, Moscow, Russia
[2] Moldavian Acad Sci, Inst Genet & Plant Physiol, Kishinev, Moldova
[3] Nicolae Testemitanu State Med & Pharmaceut Univ, Kishinev, Moldova
[4] Russian State Med Univ, Medicobiol Fac, Dept Fundamental & Clin Neurol & Neurosurg, Moscow 117437, Russia
来源：
MOLECULAR GENETICS MICROBIOLOGY AND VIROLOGY | 2011年 / 26卷 / 02期
基金：
俄罗斯基础研究基金会;
关键词：
ischemic stroke; polymorphic variants; ISCHEMIC-STROKE; PHOSPHODIESTERASE; 4D; RISK; ASSOCIATION; ATHEROSCLEROSIS; 5Q12;
D O I：
10.3103/S0891416811020030
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The risk of the development of ischemic stroke is caused by both genetic predisposition and environmental factors. In recent investigations, the DeCode group discovered polymorphisms in the phosphodiesterase 4D (PDE4D) gene associated with the risk of the development of ischemic stroke. The aim of the present work was to investigate two polymorphisms in the PDE4D gene (SNP41 (rs52312) and SNP87 (rs2910829)) in patients with ischemic stroke and in the control sample from the Moldavian ethnic group. Statistically significant data about the association between ischemic stroke and studied polymorphisms were not detected.
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页码：50 / 53
页数：4
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